Contribution of Streptokinase-Domains from Groups G and A (SK2a) Streptococci in Amidolytic/Proteolytic Activities and Fibrin-Dependent Plasminogen Activation: A Domain-Exchange Study

Contribution of Streptokinase-Domains from Groups G and A (SK2a) Streptococci in Amidolytic/Proteolytic Activities and Fibrin-Dependent Plasminogen Activation: A Domain-Exchange Study

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Background: Streptokinase (SK), a heterogeneous plasminogen activator (PA) protein from groups A, C, and G streptococci (GAS, GCS, GGS, respectively) contains three structural domains (SKα, SKβ, and SKg). Based on the variable region of SKβ, GAS-SKs (ska) are clustered as SK1 and SK2 (including clus...

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Bibliographic Details
Main Authors: Maryam Rafipour, Malihe Keramati, Mohammad Mehdi Aslani, Arash Arashkia, Farzin Roohvand
Format: Article
Language:English
Published: Pasteur Institute of Iran 2020-01-01
Series:Iranian Biomedical Journal
Subjects:
plasminogen
streptokinase
thrombolytic therapy
Online Access:http://ibj.pasteur.ac.ir/article-1-2859-en.html

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