Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis
Abstract Objectives we performed this meta- analysis to investigate the impact of insulin receptor substrate 1 (IRS1) gene rs1801278 on susceptibility to gestational diabetes mellitus (GDM). Methods The pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated, and p value is used...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-024-01289-w |
| _version_ | 1797266739586662400 |
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| author | Lili Shen Junli Liu Xiaolei Zhao Aiqin Wang Xiaomei Hu |
| author_facet | Lili Shen Junli Liu Xiaolei Zhao Aiqin Wang Xiaomei Hu |
| author_sort | Lili Shen |
| collection | DOAJ |
| description | Abstract Objectives we performed this meta- analysis to investigate the impact of insulin receptor substrate 1 (IRS1) gene rs1801278 on susceptibility to gestational diabetes mellitus (GDM). Methods The pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated, and p value is used to determine statistical significance. Sensitivity analysis was performed under three models (dominant, recessive and allele model), and the pooled ORs and 95%CI were calculated. Funnel plots and Begger’s regression test were employed to test the publication bias. Results The meta-analysis included 4777 participants (2116 cases and 2661 controls). The IRS1 rs1801278 (C/T) were not significant associated with GDM risk under the dominant and allele models, OR (95%CI) = 1.22 (0.88–1.70) and 1.24 (0.91–1.68), respectively (both p values were more than 0.05). But we also found the IRS1 rs1801278 (C/T) were significant associated with GDM risk under the recessive model, OR (95%CI) = 0.37 (0.16–0.86), p = 0.030. Our results showed that none of the studies affected the quality of the pooled OR. We also found no significant publication bias existed in this meta study for three genetic models, P TT + CT vs. CC = 0.445; P CC+CT vs. TT= 0.095; P C vs. T = 0.697. Conclusion this meta-analysis indicated that IRS1 rs1801278 (C/T) was associated with the GDM risk under the recessive model but was not associated with the GDM risk under dominant and allele models. |
| first_indexed | 2024-04-25T01:05:29Z |
| format | Article |
| id | doaj.art-fac13a4163cf4259a3b282003f5b6eff |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-25T01:05:29Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-fac13a4163cf4259a3b282003f5b6eff2024-03-10T12:18:35ZengBMCDiabetology & Metabolic Syndrome1758-59962024-03-011611710.1186/s13098-024-01289-wAssociation between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysisLili Shen0Junli Liu1Xiaolei Zhao2Aiqin Wang3Xiaomei Hu4Department of Obstetrics and Gynecology, Heping Hospital Affiliated to Changzhi Medical CollegeDepartment of Obstetrics and Gynecology, Heping Hospital Affiliated to Changzhi Medical CollegeDepartment of Obstetrics and Gynecology, Heping Hospital Affiliated to Changzhi Medical CollegeDepartment of Obstetrics and Gynecology, Heping Hospital Affiliated to Changzhi Medical CollegeDepartment of Obstetrics and Gynecology, Heping Hospital Affiliated to Changzhi Medical CollegeAbstract Objectives we performed this meta- analysis to investigate the impact of insulin receptor substrate 1 (IRS1) gene rs1801278 on susceptibility to gestational diabetes mellitus (GDM). Methods The pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated, and p value is used to determine statistical significance. Sensitivity analysis was performed under three models (dominant, recessive and allele model), and the pooled ORs and 95%CI were calculated. Funnel plots and Begger’s regression test were employed to test the publication bias. Results The meta-analysis included 4777 participants (2116 cases and 2661 controls). The IRS1 rs1801278 (C/T) were not significant associated with GDM risk under the dominant and allele models, OR (95%CI) = 1.22 (0.88–1.70) and 1.24 (0.91–1.68), respectively (both p values were more than 0.05). But we also found the IRS1 rs1801278 (C/T) were significant associated with GDM risk under the recessive model, OR (95%CI) = 0.37 (0.16–0.86), p = 0.030. Our results showed that none of the studies affected the quality of the pooled OR. We also found no significant publication bias existed in this meta study for three genetic models, P TT + CT vs. CC = 0.445; P CC+CT vs. TT= 0.095; P C vs. T = 0.697. Conclusion this meta-analysis indicated that IRS1 rs1801278 (C/T) was associated with the GDM risk under the recessive model but was not associated with the GDM risk under dominant and allele models.https://doi.org/10.1186/s13098-024-01289-wIRS1PolymorphismT2DMMeta-analysis |
| spellingShingle | Lili Shen Junli Liu Xiaolei Zhao Aiqin Wang Xiaomei Hu Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis Diabetology & Metabolic Syndrome IRS1 Polymorphism T2DM Meta-analysis |
| title | Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis |
| title_full | Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis |
| title_fullStr | Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis |
| title_full_unstemmed | Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis |
| title_short | Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis |
| title_sort | association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus an updated meta analysis |
| topic | IRS1 Polymorphism T2DM Meta-analysis |
| url | https://doi.org/10.1186/s13098-024-01289-w |
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