Comparison of time to negative conversion of SARS-CoV-2 between young and elderly among asymptomatic and mild COVID-19 patients: a cohort study from a national containment center
ObjectiveWe aimed to study the relationship between age and time to negative conversion of SARS-CoV-2 in patients with asymptomatic and mild forms of COVID-19.MethodsWe conducted a cohort study including all patients diagnosed with COVID-19 from the national COVID-19 containment center of Tunisia. P...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1217849/full |
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| author | Imen Zemni Imen Zemni Imen Zemni Cyrine Bennasrallah Cyrine Bennasrallah Cyrine Bennasrallah Ines Charrada Wafa Dhouib Wafa Dhouib Wafa Dhouib Amani Maatouk Donia Ben Hassine Donia Ben Hassine Rim Klii Meriem Kacem Meriem Kacem Meriem Kacem Manel Ben Fredj Manel Ben Fredj Manel Ben Fredj Hela Abroug Hela Abroug Hela Abroug Salma Mhalla Maha Mastouri Chawki Loussaief Ines Jlassi Ines Bouanène Ines Bouanène Asma Sriha Belguith Asma Sriha Belguith Asma Sriha Belguith |
| author_facet | Imen Zemni Imen Zemni Imen Zemni Cyrine Bennasrallah Cyrine Bennasrallah Cyrine Bennasrallah Ines Charrada Wafa Dhouib Wafa Dhouib Wafa Dhouib Amani Maatouk Donia Ben Hassine Donia Ben Hassine Rim Klii Meriem Kacem Meriem Kacem Meriem Kacem Manel Ben Fredj Manel Ben Fredj Manel Ben Fredj Hela Abroug Hela Abroug Hela Abroug Salma Mhalla Maha Mastouri Chawki Loussaief Ines Jlassi Ines Bouanène Ines Bouanène Asma Sriha Belguith Asma Sriha Belguith Asma Sriha Belguith |
| author_sort | Imen Zemni |
| collection | DOAJ |
| description | ObjectiveWe aimed to study the relationship between age and time to negative conversion of SARS-CoV-2 in patients with asymptomatic and mild forms of COVID-19.MethodsWe conducted a cohort study including all patients diagnosed with COVID-19 from the national COVID-19 containment center of Tunisia. Patients were subdivided into two cohorts: (under 60 years) and (over 60 years) and were followed up until PCR negativization. Log rank test and Cox regression were applied to compare time to negative conversion between the old group and the young group.ResultsThe study included 289 patients with non-severe forms of COVID-19. Age over 60 was significantly associated with delayed negative conversion in male sex (Hazard ratio (HR): 1.9; 95% CI: 1.2–3.07) and among patients with morbid conditions (HR:1.68; 95% CI: 1.02–2.75) especially diabetics (HR: 2.06; 95% CI: 1.01–4.21). This association increased to (HR:2.3; 95% CI: 1.13–4.66) when male sex and comorbidities were concomitantly present and rose to (HR: 2.63; 95% CI: 1.02–6.80) for men with diabetes. Cox regression analysis revealed a significantly delayed negative conversion in symptomatic patients. Significant interaction was observed between gender and age and between age and chronic conditions.ConclusionAge is associated with delayed negative conversion of viral RNA in certain subgroups. Identifying these subgroups is crucial to know how prioritize preventive strategies in elderly. |
| first_indexed | 2024-04-24T22:45:18Z |
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| id | doaj.art-fac3b404aaf8464993794b1434b67463 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-24T22:45:18Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-fac3b404aaf8464993794b1434b674632024-03-18T13:20:50ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-03-011110.3389/fmed.2024.12178491217849Comparison of time to negative conversion of SARS-CoV-2 between young and elderly among asymptomatic and mild COVID-19 patients: a cohort study from a national containment centerImen Zemni0Imen Zemni1Imen Zemni2Cyrine Bennasrallah3Cyrine Bennasrallah4Cyrine Bennasrallah5Ines Charrada6Wafa Dhouib7Wafa Dhouib8Wafa Dhouib9Amani Maatouk10Donia Ben Hassine11Donia Ben Hassine12Rim Klii13Meriem Kacem14Meriem Kacem15Meriem Kacem16Manel Ben Fredj17Manel Ben Fredj18Manel Ben Fredj19Hela Abroug20Hela Abroug21Hela Abroug22Salma Mhalla23Maha Mastouri24Chawki Loussaief25Ines Jlassi26Ines Bouanène27Ines Bouanène28Asma Sriha Belguith29Asma Sriha Belguith30Asma Sriha Belguith31Department of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaFaculty of Medicine of Monastir, Department of Epidemiology, University of Monastir, Monastir, TunisiaTechnology and Medical Imaging Research Laboratory, University of Monastir, Monastir, TunisiaDepartment of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaFaculty of Medicine of Monastir, Department of Epidemiology, University of Monastir, Monastir, TunisiaTechnology and Medical Imaging Research Laboratory, University of Monastir, Monastir, TunisiaDepartment of Endocrinology, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaDepartment of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaFaculty of Medicine of Monastir, Department of Epidemiology, University of Monastir, Monastir, TunisiaTechnology and Medical Imaging Research Laboratory, University of Monastir, Monastir, TunisiaDepartment of Microbiology, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaDepartment of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaFaculty of Medicine of Monastir, Department of Epidemiology, University of Monastir, Monastir, TunisiaDepartment of Internal Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaDepartment of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaFaculty of Medicine of Monastir, Department of Epidemiology, University of Monastir, Monastir, TunisiaTechnology and Medical Imaging Research Laboratory, University of Monastir, Monastir, TunisiaDepartment of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaFaculty of Medicine of Monastir, Department of Epidemiology, University of Monastir, Monastir, TunisiaTechnology and Medical Imaging Research Laboratory, University of Monastir, Monastir, TunisiaDepartment of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaFaculty of Medicine of Monastir, Department of Epidemiology, University of Monastir, Monastir, TunisiaTechnology and Medical Imaging Research Laboratory, University of Monastir, Monastir, TunisiaDepartment of Microbiology, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaDepartment of Microbiology, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaDepartment of Infectiology, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaFaculty of Sciences of Monastir, Department of Mathematics and Statistics, University of Monastir, Monastir, TunisiaDepartment of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaFaculty of Medicine of Monastir, Department of Epidemiology, University of Monastir, Monastir, TunisiaDepartment of Epidemiology and Preventive Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, TunisiaFaculty of Medicine of Monastir, Department of Epidemiology, University of Monastir, Monastir, TunisiaTechnology and Medical Imaging Research Laboratory, University of Monastir, Monastir, TunisiaObjectiveWe aimed to study the relationship between age and time to negative conversion of SARS-CoV-2 in patients with asymptomatic and mild forms of COVID-19.MethodsWe conducted a cohort study including all patients diagnosed with COVID-19 from the national COVID-19 containment center of Tunisia. Patients were subdivided into two cohorts: (under 60 years) and (over 60 years) and were followed up until PCR negativization. Log rank test and Cox regression were applied to compare time to negative conversion between the old group and the young group.ResultsThe study included 289 patients with non-severe forms of COVID-19. Age over 60 was significantly associated with delayed negative conversion in male sex (Hazard ratio (HR): 1.9; 95% CI: 1.2–3.07) and among patients with morbid conditions (HR:1.68; 95% CI: 1.02–2.75) especially diabetics (HR: 2.06; 95% CI: 1.01–4.21). This association increased to (HR:2.3; 95% CI: 1.13–4.66) when male sex and comorbidities were concomitantly present and rose to (HR: 2.63; 95% CI: 1.02–6.80) for men with diabetes. Cox regression analysis revealed a significantly delayed negative conversion in symptomatic patients. Significant interaction was observed between gender and age and between age and chronic conditions.ConclusionAge is associated with delayed negative conversion of viral RNA in certain subgroups. Identifying these subgroups is crucial to know how prioritize preventive strategies in elderly.https://www.frontiersin.org/articles/10.3389/fmed.2024.1217849/fullCOVID-19elderlypandemicviral clearancemild COVID-19 infection |
| spellingShingle | Imen Zemni Imen Zemni Imen Zemni Cyrine Bennasrallah Cyrine Bennasrallah Cyrine Bennasrallah Ines Charrada Wafa Dhouib Wafa Dhouib Wafa Dhouib Amani Maatouk Donia Ben Hassine Donia Ben Hassine Rim Klii Meriem Kacem Meriem Kacem Meriem Kacem Manel Ben Fredj Manel Ben Fredj Manel Ben Fredj Hela Abroug Hela Abroug Hela Abroug Salma Mhalla Maha Mastouri Chawki Loussaief Ines Jlassi Ines Bouanène Ines Bouanène Asma Sriha Belguith Asma Sriha Belguith Asma Sriha Belguith Comparison of time to negative conversion of SARS-CoV-2 between young and elderly among asymptomatic and mild COVID-19 patients: a cohort study from a national containment center Frontiers in Medicine COVID-19 elderly pandemic viral clearance mild COVID-19 infection |
| title | Comparison of time to negative conversion of SARS-CoV-2 between young and elderly among asymptomatic and mild COVID-19 patients: a cohort study from a national containment center |
| title_full | Comparison of time to negative conversion of SARS-CoV-2 between young and elderly among asymptomatic and mild COVID-19 patients: a cohort study from a national containment center |
| title_fullStr | Comparison of time to negative conversion of SARS-CoV-2 between young and elderly among asymptomatic and mild COVID-19 patients: a cohort study from a national containment center |
| title_full_unstemmed | Comparison of time to negative conversion of SARS-CoV-2 between young and elderly among asymptomatic and mild COVID-19 patients: a cohort study from a national containment center |
| title_short | Comparison of time to negative conversion of SARS-CoV-2 between young and elderly among asymptomatic and mild COVID-19 patients: a cohort study from a national containment center |
| title_sort | comparison of time to negative conversion of sars cov 2 between young and elderly among asymptomatic and mild covid 19 patients a cohort study from a national containment center |
| topic | COVID-19 elderly pandemic viral clearance mild COVID-19 infection |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1217849/full |
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