High-fat diet reveals the impact of Sar1b defects on lipid and lipoprotein profile and cholesterol metabolism

High-fat diet reveals the impact of Sar1b defects on lipid and lipoprotein profile and cholesterol metabolism

Biallelic pathogenic variants of the Sar1b gene cause chylomicron retention disease (CRD) whose central phenotype is the inability to secrete chylomicrons. Patients with CRD experience numerous clinical symptoms such as gastrointestinal, hepatic, neuromuscular, ophthalmic, and cardiological abnormal...

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Bibliographic Details
Main Authors: Nickolas Auclair, Alain T. Sané, Léna Ahmarani, Nour-El-Houda Ould-Chikh, Nathalie Patey, Jean-François Beaulieu, Edgard Delvin, Schohraya Spahis, Emile Levy
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Lipid Research
Subjects:
Sar1b gene
chylomicron
intestinal fat malabsorption
lipoprotein composition
embryonic lethality
high-fat diet
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523000962

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