Antibiotics biomonitored in urine and obesogenic risk in a community-dwelling elderly population
Background: Experimental and epidemiological studies have linked antibiotics use to gut dysbiosis-mediated risk of chronic metabolic diseases. However, whether adiposity is linked to antibiotic exposure in elderly remains inadequately understood. Objective: To investigate the association between int...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651320316997 |
| _version_ | 1819090738386829312 |
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| author | Yanru Sang Jingjing Zhang Kaiyong Liu Qunan Wang Sufang Wang Jie Sheng Li Wang Dongmei Zhang Xiude Li Hongjuan Cao Annuo Liu Fangbiao Tao |
| author_facet | Yanru Sang Jingjing Zhang Kaiyong Liu Qunan Wang Sufang Wang Jie Sheng Li Wang Dongmei Zhang Xiude Li Hongjuan Cao Annuo Liu Fangbiao Tao |
| author_sort | Yanru Sang |
| collection | DOAJ |
| description | Background: Experimental and epidemiological studies have linked antibiotics use to gut dysbiosis-mediated risk of chronic metabolic diseases. However, whether adiposity is linked to antibiotic exposure in elderly remains inadequately understood. Objective: To investigate the association between internal exposure of antibiotics and adiposity in elderly by using a biomonitoring method. Methods: We included 990 participants (≥60 years) from the baseline survey of the Cohort of Elderly Health and Environment Controllable Factors in Lu’an city, China, from June to September 2016. Forty-five antibiotics and two metabolites in urine were monitored through liquid chromatography-electrospray tandem mass spectrometry (HPLC-MS/MS). Creatinine-corrected urinary concentrations were used to assess antibiotic exposure levels. Body mass index (BMI), waist circumference (WC) and body fat percentage (BFP) were used as indicators of adiposity. Multiple linear regression and binary logistic regression analyses were used to analyze the association of antibiotic concentrations with obesity-related indices. Subsequently, a gender-stratified analysis was performed. Results: Of the included elderly, 50.7% were defined as having overweight/ obesity, 59.8% as having central preobesity/obesity, and 37.5% as having slightly high/high BFP. Linear regression analysis revealed that a 1-unit increase in the logarithmic transformation of norfloxacin concentrations was related with an increase of 0.29 kg/m2 (95% CI: 0.02–0.04), 0.99 cm (95% CI：0.24–1.75), and 0.69% (95% CI：0.21–1.17) in BMI, WC, and BFP, respectively. Compared with the control group, exposure to doxycycline (tertile 2: odds ratio, 2.06 [95% CI: 1.12–3.76]) and norfloxacin (tertile 2: 2.13 [1.05–4.29]; tertile 3: 2.07 [1.03–4.17]) had BMI-based overweight/obesity risk. Additionally, ciprofloxacin (tertile 2: 2.06 [1.12–3.76]), norfloxacin (tertile 3: 2.95 [1.34–6.49]), and florfenicol (tertile 3: 1.84 [1.07–3.14]) were related to WC-based central preobesity/obesity risk. Norfloxacin (tertile 3: 2.54 [1.23–5.24]) was positively associated with a slightly high/high BFP risk. Gender-stratified analysis demonstrated an increased adiposity risk in women compared with men. Conclusions: Our research provided an evidence that exposure to specific types of antibiotics (tetracyclines and fluoroquinolones) probably from the food chain contributed to obesity in elderly. Prospective cohort studies with larger sample size are warrented to explore the causation. |
| first_indexed | 2024-12-21T22:28:36Z |
| format | Article |
| id | doaj.art-fac7c273dba6468c8af74f60a50f72dd |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-21T22:28:36Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-fac7c273dba6468c8af74f60a50f72dd2022-12-21T18:48:09ZengElsevierEcotoxicology and Environmental Safety0147-65132021-03-01210111863Antibiotics biomonitored in urine and obesogenic risk in a community-dwelling elderly populationYanru Sang0Jingjing Zhang1Kaiyong Liu2Qunan Wang3Sufang Wang4Jie Sheng5Li Wang6Dongmei Zhang7Xiude Li8Hongjuan Cao9Annuo Liu10Fangbiao Tao11School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University)，Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, No 81 Meishan Road, Hefei 230032, Anhui, China; School of Health Management, Anhui Medical University, Hefei 230032, ChinaSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University)，Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, No 81 Meishan Road, Hefei 230032, Anhui, China; School of Health Management, Anhui Medical University, Hefei 230032, ChinaSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University)，Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, No 81 Meishan Road, Hefei 230032, Anhui, China; School of Health Management, Anhui Medical University, Hefei 230032, China; Correspondence to: No 81 Meishan Road, Hefei 230032, Anhui, China.School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, ChinaSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, ChinaSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, ChinaSchool of Health Management, Anhui Medical University, Hefei 230032, ChinaSchool of Health Management, Anhui Medical University, Hefei 230032, ChinaLu’an Center of Disease Control and Prevention, Lu’an 237000, Anhui, ChinaLu’an Center of Disease Control and Prevention, Lu’an 237000, Anhui, ChinaSchool of Nursing, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University)，Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, No 81 Meishan Road, Hefei 230032, Anhui, China; School of Health Management, Anhui Medical University, Hefei 230032, ChinaBackground: Experimental and epidemiological studies have linked antibiotics use to gut dysbiosis-mediated risk of chronic metabolic diseases. However, whether adiposity is linked to antibiotic exposure in elderly remains inadequately understood. Objective: To investigate the association between internal exposure of antibiotics and adiposity in elderly by using a biomonitoring method. Methods: We included 990 participants (≥60 years) from the baseline survey of the Cohort of Elderly Health and Environment Controllable Factors in Lu’an city, China, from June to September 2016. Forty-five antibiotics and two metabolites in urine were monitored through liquid chromatography-electrospray tandem mass spectrometry (HPLC-MS/MS). Creatinine-corrected urinary concentrations were used to assess antibiotic exposure levels. Body mass index (BMI), waist circumference (WC) and body fat percentage (BFP) were used as indicators of adiposity. Multiple linear regression and binary logistic regression analyses were used to analyze the association of antibiotic concentrations with obesity-related indices. Subsequently, a gender-stratified analysis was performed. Results: Of the included elderly, 50.7% were defined as having overweight/ obesity, 59.8% as having central preobesity/obesity, and 37.5% as having slightly high/high BFP. Linear regression analysis revealed that a 1-unit increase in the logarithmic transformation of norfloxacin concentrations was related with an increase of 0.29 kg/m2 (95% CI: 0.02–0.04), 0.99 cm (95% CI：0.24–1.75), and 0.69% (95% CI：0.21–1.17) in BMI, WC, and BFP, respectively. Compared with the control group, exposure to doxycycline (tertile 2: odds ratio, 2.06 [95% CI: 1.12–3.76]) and norfloxacin (tertile 2: 2.13 [1.05–4.29]; tertile 3: 2.07 [1.03–4.17]) had BMI-based overweight/obesity risk. Additionally, ciprofloxacin (tertile 2: 2.06 [1.12–3.76]), norfloxacin (tertile 3: 2.95 [1.34–6.49]), and florfenicol (tertile 3: 1.84 [1.07–3.14]) were related to WC-based central preobesity/obesity risk. Norfloxacin (tertile 3: 2.54 [1.23–5.24]) was positively associated with a slightly high/high BFP risk. Gender-stratified analysis demonstrated an increased adiposity risk in women compared with men. Conclusions: Our research provided an evidence that exposure to specific types of antibiotics (tetracyclines and fluoroquinolones) probably from the food chain contributed to obesity in elderly. Prospective cohort studies with larger sample size are warrented to explore the causation.http://www.sciencedirect.com/science/article/pii/S0147651320316997AntibioticsUrineBiomonitoringElderlyAdiposity |
| spellingShingle | Yanru Sang Jingjing Zhang Kaiyong Liu Qunan Wang Sufang Wang Jie Sheng Li Wang Dongmei Zhang Xiude Li Hongjuan Cao Annuo Liu Fangbiao Tao Antibiotics biomonitored in urine and obesogenic risk in a community-dwelling elderly population Ecotoxicology and Environmental Safety Antibiotics Urine Biomonitoring Elderly Adiposity |
| title | Antibiotics biomonitored in urine and obesogenic risk in a community-dwelling elderly population |
| title_full | Antibiotics biomonitored in urine and obesogenic risk in a community-dwelling elderly population |
| title_fullStr | Antibiotics biomonitored in urine and obesogenic risk in a community-dwelling elderly population |
| title_full_unstemmed | Antibiotics biomonitored in urine and obesogenic risk in a community-dwelling elderly population |
| title_short | Antibiotics biomonitored in urine and obesogenic risk in a community-dwelling elderly population |
| title_sort | antibiotics biomonitored in urine and obesogenic risk in a community dwelling elderly population |
| topic | Antibiotics Urine Biomonitoring Elderly Adiposity |
| url | http://www.sciencedirect.com/science/article/pii/S0147651320316997 |
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