Irreversible Electroporation of the Hepatobiliary System: Current Utilization and Future Avenues
Liver cancer remains a leading cause of cancer-related deaths worldwide despite numerous advances in treatment. While surgical resection remains the gold standard for curative treatment, it is only possible for a minority of patients. Thermal ablation is an effective option for the treatment of smal...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/60/2/251 |
| _version_ | 1797297580340674560 |
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| author | Govindarajan Narayanan Yilun Koethe Nicole Gentile |
| author_facet | Govindarajan Narayanan Yilun Koethe Nicole Gentile |
| author_sort | Govindarajan Narayanan |
| collection | DOAJ |
| description | Liver cancer remains a leading cause of cancer-related deaths worldwide despite numerous advances in treatment. While surgical resection remains the gold standard for curative treatment, it is only possible for a minority of patients. Thermal ablation is an effective option for the treatment of smaller tumors; however, its use is limited to tumors that are not located in proximity to sensitive structures due to the heat sink effect and the potential of thermal damage. Irreversible electroporation (IRE) is a non-thermal ablative modality that can deliver targeted treatment and the effective destruction of tumors that are in close proximity to or even surrounding vascular or biliary ducts with minimal damage to these structures. IRE produces short pulses of high-frequency energy which opens pores in the lipid bilayer of cells leading to apoptosis and cell death. IRE has been utilized clinically for over a decade in the treatment of liver cancers with multiple studies documenting an acceptable safety profile and high efficacy rates. |
| first_indexed | 2024-03-07T22:22:24Z |
| format | Article |
| id | doaj.art-fac8d182ce2f461e8d52e9bf34622454 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-07T22:22:24Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-fac8d182ce2f461e8d52e9bf346224542024-02-23T15:26:33ZengMDPI AGMedicina1010-660X1648-91442024-01-0160225110.3390/medicina60020251Irreversible Electroporation of the Hepatobiliary System: Current Utilization and Future AvenuesGovindarajan Narayanan0Yilun Koethe1Nicole Gentile2Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USATRG Imaging, Portland, OR 97225, USAMiami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USALiver cancer remains a leading cause of cancer-related deaths worldwide despite numerous advances in treatment. While surgical resection remains the gold standard for curative treatment, it is only possible for a minority of patients. Thermal ablation is an effective option for the treatment of smaller tumors; however, its use is limited to tumors that are not located in proximity to sensitive structures due to the heat sink effect and the potential of thermal damage. Irreversible electroporation (IRE) is a non-thermal ablative modality that can deliver targeted treatment and the effective destruction of tumors that are in close proximity to or even surrounding vascular or biliary ducts with minimal damage to these structures. IRE produces short pulses of high-frequency energy which opens pores in the lipid bilayer of cells leading to apoptosis and cell death. IRE has been utilized clinically for over a decade in the treatment of liver cancers with multiple studies documenting an acceptable safety profile and high efficacy rates.https://www.mdpi.com/1648-9144/60/2/251liver cancerirreversible electroporationhepatocellular carcinomaliver metastasescholangiocarcinoma |
| spellingShingle | Govindarajan Narayanan Yilun Koethe Nicole Gentile Irreversible Electroporation of the Hepatobiliary System: Current Utilization and Future Avenues Medicina liver cancer irreversible electroporation hepatocellular carcinoma liver metastases cholangiocarcinoma |
| title | Irreversible Electroporation of the Hepatobiliary System: Current Utilization and Future Avenues |
| title_full | Irreversible Electroporation of the Hepatobiliary System: Current Utilization and Future Avenues |
| title_fullStr | Irreversible Electroporation of the Hepatobiliary System: Current Utilization and Future Avenues |
| title_full_unstemmed | Irreversible Electroporation of the Hepatobiliary System: Current Utilization and Future Avenues |
| title_short | Irreversible Electroporation of the Hepatobiliary System: Current Utilization and Future Avenues |
| title_sort | irreversible electroporation of the hepatobiliary system current utilization and future avenues |
| topic | liver cancer irreversible electroporation hepatocellular carcinoma liver metastases cholangiocarcinoma |
| url | https://www.mdpi.com/1648-9144/60/2/251 |
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