Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus
Abstract Background Underweight imposes significant burden on cardiovascular outcomes in patients with diabetes mellitus. However, less is known about the impact of serial change in body weight status measured as body mass index (BMI) on the risk of sudden cardiac arrest (SCA). This study investigat...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-024-02130-4 |
| _version_ | 1797276028949757952 |
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| author | Joo Hee Jeong Yun Gi Kim Kyung-Do Han Seung-Young Roh Hyoung Seok Lee Yun Young Choi Jaemin Shim Jong-Il Choi Young-Hoon Kim |
| author_facet | Joo Hee Jeong Yun Gi Kim Kyung-Do Han Seung-Young Roh Hyoung Seok Lee Yun Young Choi Jaemin Shim Jong-Il Choi Young-Hoon Kim |
| author_sort | Joo Hee Jeong |
| collection | DOAJ |
| description | Abstract Background Underweight imposes significant burden on cardiovascular outcomes in patients with diabetes mellitus. However, less is known about the impact of serial change in body weight status measured as body mass index (BMI) on the risk of sudden cardiac arrest (SCA). This study investigated the association between SCA and temporal change in BMI among patients with diabetes mellitus. Methods Based on Korean National Health Insurance Service database, participants with diabetes mellitus who underwent health examination between 2009 and 2012 and had prior health examination data (four years ago, 2005–2008) were retrospectively analyzed. BMI was measured at baseline (2005–2008) and 4-year follow-up health examination (2009–2012). Patients were classified in four groups according to the body weight status and its temporal change: sustained non-underweight, sustained underweight, previous underweight, and newly developed underweight. Primary outcome was defined as occurrence of SCA. Results A total of 1,355,746 patients with diabetes mellitus were included for analysis, and SCA occurred in 12,554 cases. SCA was most common in newly developed underweight (incidence rate = 4.45 per 1,000 person-years), followed by sustained underweight (incidence rate = 3.90), previous underweight (incidence rate = 3.03), and sustained non-underweight (incidence rate = 1.34). Adjustment of covariates resulted highest risk of SCA in sustained underweight (adjusted hazard ratio = 2.60, 95% confidence interval [2.25–3.00], sustained non-underweight as a reference), followed by newly developed underweight (2.42, [2.15–2.74]), and previous underweight (2.12, [1.77–2.53]). Conclusions In diabetes mellitus, sustained underweight as well as decrease in body weight during 4-year follow-up imposes substantial risk on SCA. Recovery from underweight over time had relatively lower, but yet increased risk of SCA. Both underweight and dynamic decrease in BMI can be associated with increased risk of SCA. |
| first_indexed | 2024-03-07T15:22:27Z |
| format | Article |
| id | doaj.art-fac98d1d798d4656868ef7a9e3ade87c |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-07T15:22:27Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-fac98d1d798d4656868ef7a9e3ade87c2024-03-05T17:36:36ZengBMCCardiovascular Diabetology1475-28402024-01-0123111010.1186/s12933-024-02130-4Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitusJoo Hee Jeong0Yun Gi Kim1Kyung-Do Han2Seung-Young Roh3Hyoung Seok Lee4Yun Young Choi5Jaemin Shim6Jong-Il Choi7Young-Hoon Kim8Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Korea University Anam HospitalDepartment of Statistics and Actuarial Science, Soongsil UniversityDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Korea University Guro HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Korea University Anam HospitalAbstract Background Underweight imposes significant burden on cardiovascular outcomes in patients with diabetes mellitus. However, less is known about the impact of serial change in body weight status measured as body mass index (BMI) on the risk of sudden cardiac arrest (SCA). This study investigated the association between SCA and temporal change in BMI among patients with diabetes mellitus. Methods Based on Korean National Health Insurance Service database, participants with diabetes mellitus who underwent health examination between 2009 and 2012 and had prior health examination data (four years ago, 2005–2008) were retrospectively analyzed. BMI was measured at baseline (2005–2008) and 4-year follow-up health examination (2009–2012). Patients were classified in four groups according to the body weight status and its temporal change: sustained non-underweight, sustained underweight, previous underweight, and newly developed underweight. Primary outcome was defined as occurrence of SCA. Results A total of 1,355,746 patients with diabetes mellitus were included for analysis, and SCA occurred in 12,554 cases. SCA was most common in newly developed underweight (incidence rate = 4.45 per 1,000 person-years), followed by sustained underweight (incidence rate = 3.90), previous underweight (incidence rate = 3.03), and sustained non-underweight (incidence rate = 1.34). Adjustment of covariates resulted highest risk of SCA in sustained underweight (adjusted hazard ratio = 2.60, 95% confidence interval [2.25–3.00], sustained non-underweight as a reference), followed by newly developed underweight (2.42, [2.15–2.74]), and previous underweight (2.12, [1.77–2.53]). Conclusions In diabetes mellitus, sustained underweight as well as decrease in body weight during 4-year follow-up imposes substantial risk on SCA. Recovery from underweight over time had relatively lower, but yet increased risk of SCA. Both underweight and dynamic decrease in BMI can be associated with increased risk of SCA.https://doi.org/10.1186/s12933-024-02130-4UnderweightDiabetes mellitusSudden cardiac arrest |
| spellingShingle | Joo Hee Jeong Yun Gi Kim Kyung-Do Han Seung-Young Roh Hyoung Seok Lee Yun Young Choi Jaemin Shim Jong-Il Choi Young-Hoon Kim Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus Cardiovascular Diabetology Underweight Diabetes mellitus Sudden cardiac arrest |
| title | Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus |
| title_full | Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus |
| title_fullStr | Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus |
| title_full_unstemmed | Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus |
| title_short | Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus |
| title_sort | association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus |
| topic | Underweight Diabetes mellitus Sudden cardiac arrest |
| url | https://doi.org/10.1186/s12933-024-02130-4 |
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