Progresses in understanding trauma-induced coagulopathy and the underlying mechanism
Trauma-induced coagulopathy (TIC) is a clinical syndrome caused by imbalance between clotting, anti-coagulation and fibrinolysis resulting from multiple pathological factors such as hemorrhage and tissue injury in the early stage of trauma, and is closely related to the outcome of trauma patients. I...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-06-01
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| Series: | Chinese Journal of Traumatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1008127516303248 |
| _version_ | 1819132227983769600 |
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| author | Na Peng Lei Su |
| author_facet | Na Peng Lei Su |
| author_sort | Na Peng |
| collection | DOAJ |
| description | Trauma-induced coagulopathy (TIC) is a clinical syndrome caused by imbalance between clotting, anti-coagulation and fibrinolysis resulting from multiple pathological factors such as hemorrhage and tissue injury in the early stage of trauma, and is closely related to the outcome of trauma patients. It is proved in growing evidence that the endogenous coagulation disturbance in trauma itself is the activating factor of TIC, rather than dilution or other acquired coagulopathy. Therefore, a thorough understanding of the molecular mechanisms in the pathogenesis and progression is crucial for effective prevention and treatment in patients with TIC. This review focuses on transitions in the concept of TIC and mechanical progress. |
| first_indexed | 2024-12-22T09:28:03Z |
| format | Article |
| id | doaj.art-facc782c7c954ba38ca71bdd4a3abdc3 |
| institution | Directory Open Access Journal |
| issn | 1008-1275 |
| language | English |
| last_indexed | 2024-12-22T09:28:03Z |
| publishDate | 2017-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chinese Journal of Traumatology |
| spelling | doaj.art-facc782c7c954ba38ca71bdd4a3abdc32022-12-21T18:31:01ZengElsevierChinese Journal of Traumatology1008-12752017-06-0120313313610.1016/j.cjtee.2017.03.002Progresses in understanding trauma-induced coagulopathy and the underlying mechanismNa PengLei SuTrauma-induced coagulopathy (TIC) is a clinical syndrome caused by imbalance between clotting, anti-coagulation and fibrinolysis resulting from multiple pathological factors such as hemorrhage and tissue injury in the early stage of trauma, and is closely related to the outcome of trauma patients. It is proved in growing evidence that the endogenous coagulation disturbance in trauma itself is the activating factor of TIC, rather than dilution or other acquired coagulopathy. Therefore, a thorough understanding of the molecular mechanisms in the pathogenesis and progression is crucial for effective prevention and treatment in patients with TIC. This review focuses on transitions in the concept of TIC and mechanical progress.http://www.sciencedirect.com/science/article/pii/S1008127516303248Blood coagulation disordersShockPhysiopathologyTrauma induced coagulopathy |
| spellingShingle | Na Peng Lei Su Progresses in understanding trauma-induced coagulopathy and the underlying mechanism Chinese Journal of Traumatology Blood coagulation disorders Shock Physiopathology Trauma induced coagulopathy |
| title | Progresses in understanding trauma-induced coagulopathy and the underlying mechanism |
| title_full | Progresses in understanding trauma-induced coagulopathy and the underlying mechanism |
| title_fullStr | Progresses in understanding trauma-induced coagulopathy and the underlying mechanism |
| title_full_unstemmed | Progresses in understanding trauma-induced coagulopathy and the underlying mechanism |
| title_short | Progresses in understanding trauma-induced coagulopathy and the underlying mechanism |
| title_sort | progresses in understanding trauma induced coagulopathy and the underlying mechanism |
| topic | Blood coagulation disorders Shock Physiopathology Trauma induced coagulopathy |
| url | http://www.sciencedirect.com/science/article/pii/S1008127516303248 |
| work_keys_str_mv | AT napeng progressesinunderstandingtraumainducedcoagulopathyandtheunderlyingmechanism AT leisu progressesinunderstandingtraumainducedcoagulopathyandtheunderlyingmechanism |