Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study
Despite treating depression with antidepressants, their effectiveness is often insufficient. Comparative effectiveness studies and meta-analyses show the effectiveness of antidepressants; however, they do not provide clear indications as to the choice of a specific antidepressant. The rational choic...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/6/526 |
| _version_ | 1797531894466740224 |
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| author | Sławomir Murawiec Marek Krzystanek |
| author_facet | Sławomir Murawiec Marek Krzystanek |
| author_sort | Sławomir Murawiec |
| collection | DOAJ |
| description | Despite treating depression with antidepressants, their effectiveness is often insufficient. Comparative effectiveness studies and meta-analyses show the effectiveness of antidepressants; however, they do not provide clear indications as to the choice of a specific antidepressant. The rational choice of antidepressants may be based on matching their mechanisms of action to the symptomatic profiles of depression, reflecting the heterogeneity of symptoms in different patients. The authors presented a series of cases of patients diagnosed with depression in whom at least one previous antidepressant treatment was shown to be ineffective before drug targeted symptom cluster-matching treatment (SCMT). The presented pilot study shows for the first time the effectiveness of SCMT in the different clusters of depressive symptoms. All the described patients obtained recovery from depressive symptoms after introducing drug-targeted SCMT. Once validated in clinical trials, SCMT might become an effective and rational method of selecting an antidepressant according to the individual profile of depressive symptoms, the mechanism of their formation, and the mechanism of drug action. Although the study results are preliminary, SCMT can be a way to personalize treatment, increasing the likelihood of improvement even in patients who meet criteria for treatment-resistant depression. |
| first_indexed | 2024-03-10T10:51:17Z |
| format | Article |
| id | doaj.art-facde18e59174fed819ae7c346d0c693 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T10:51:17Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-facde18e59174fed819ae7c346d0c6932023-11-21T22:16:18ZengMDPI AGPharmaceuticals1424-82472021-05-0114652610.3390/ph14060526Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot StudySławomir Murawiec0Marek Krzystanek1Harmony Medical Centre, Rondo ONZ 1, 00-124 Warszawa, PolandClinic of Psychiatric Rehabilitation, Department of Psychiatry and Psychotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Ziołowa 45/47, 40-635 Katowice, PolandDespite treating depression with antidepressants, their effectiveness is often insufficient. Comparative effectiveness studies and meta-analyses show the effectiveness of antidepressants; however, they do not provide clear indications as to the choice of a specific antidepressant. The rational choice of antidepressants may be based on matching their mechanisms of action to the symptomatic profiles of depression, reflecting the heterogeneity of symptoms in different patients. The authors presented a series of cases of patients diagnosed with depression in whom at least one previous antidepressant treatment was shown to be ineffective before drug targeted symptom cluster-matching treatment (SCMT). The presented pilot study shows for the first time the effectiveness of SCMT in the different clusters of depressive symptoms. All the described patients obtained recovery from depressive symptoms after introducing drug-targeted SCMT. Once validated in clinical trials, SCMT might become an effective and rational method of selecting an antidepressant according to the individual profile of depressive symptoms, the mechanism of their formation, and the mechanism of drug action. Although the study results are preliminary, SCMT can be a way to personalize treatment, increasing the likelihood of improvement even in patients who meet criteria for treatment-resistant depression.https://www.mdpi.com/1424-8247/14/6/526symptom clustersdepressionpersonalized treatmentantidepressantsmechanism of actionserotonin |
| spellingShingle | Sławomir Murawiec Marek Krzystanek Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study Pharmaceuticals symptom clusters depression personalized treatment antidepressants mechanism of action serotonin |
| title | Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study |
| title_full | Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study |
| title_fullStr | Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study |
| title_full_unstemmed | Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study |
| title_short | Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study |
| title_sort | symptom cluster matching antidepressant treatment a case series pilot study |
| topic | symptom clusters depression personalized treatment antidepressants mechanism of action serotonin |
| url | https://www.mdpi.com/1424-8247/14/6/526 |
| work_keys_str_mv | AT sławomirmurawiec symptomclustermatchingantidepressanttreatmentacaseseriespilotstudy AT marekkrzystanek symptomclustermatchingantidepressanttreatmentacaseseriespilotstudy |