Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects
Evidences from more than three decades of work support the function of non-duplex DNA structures called G-quadruplex (G4) in important processes like transcription and replication. In addition, G4 structures have been studied in connection with DNA base modifications and chromatin/nucleosome arrange...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/3/582 |
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| author | Antara Sengupta Akansha Ganguly Shantanu Chowdhury |
| author_facet | Antara Sengupta Akansha Ganguly Shantanu Chowdhury |
| author_sort | Antara Sengupta |
| collection | DOAJ |
| description | Evidences from more than three decades of work support the function of non-duplex DNA structures called G-quadruplex (G4) in important processes like transcription and replication. In addition, G4 structures have been studied in connection with DNA base modifications and chromatin/nucleosome arrangements. Recent work, interestingly, shows promise of G4 structures, through interaction with G4 structure-interacting proteins, in epigenetics—in both DNA and histone modification. Epigenetic changes are found to be intricately associated with initiation as well as progression of cancer. Multiple oncogenes have been reported to harbor the G4 structure at regulatory regions. In this context, G4 structure-binding ligands attain significance as molecules with potential to modify the epigenetic state of chromatin. Here, using examples from recent studies we discuss the emerging role of G4 structures in epigenetic modifications and, therefore, the promise of G4 structure-binding ligands in epigenetic therapy. |
| first_indexed | 2024-12-13T07:44:49Z |
| format | Article |
| id | doaj.art-face20ee1e6042f0a99d9fe891d3788f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T07:44:49Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-face20ee1e6042f0a99d9fe891d3788f2022-12-21T23:54:52ZengMDPI AGMolecules1420-30492019-02-0124358210.3390/molecules24030582molecules24030582Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer EffectsAntara Sengupta0Akansha Ganguly1Shantanu Chowdhury2Integrative and Functional Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi-110025, IndiaIntegrative and Functional Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi-110025, IndiaIntegrative and Functional Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi-110025, IndiaEvidences from more than three decades of work support the function of non-duplex DNA structures called G-quadruplex (G4) in important processes like transcription and replication. In addition, G4 structures have been studied in connection with DNA base modifications and chromatin/nucleosome arrangements. Recent work, interestingly, shows promise of G4 structures, through interaction with G4 structure-interacting proteins, in epigenetics—in both DNA and histone modification. Epigenetic changes are found to be intricately associated with initiation as well as progression of cancer. Multiple oncogenes have been reported to harbor the G4 structure at regulatory regions. In this context, G4 structure-binding ligands attain significance as molecules with potential to modify the epigenetic state of chromatin. Here, using examples from recent studies we discuss the emerging role of G4 structures in epigenetic modifications and, therefore, the promise of G4 structure-binding ligands in epigenetic therapy.https://www.mdpi.com/1420-3049/24/3/582epigeneticsG4-interacting proteinsdietary G4 structure-binding moleculeshistoneschromatinreplication |
| spellingShingle | Antara Sengupta Akansha Ganguly Shantanu Chowdhury Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects Molecules epigenetics G4-interacting proteins dietary G4 structure-binding molecules histones chromatin replication |
| title | Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects |
| title_full | Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects |
| title_fullStr | Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects |
| title_full_unstemmed | Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects |
| title_short | Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects |
| title_sort | promise of g quadruplex structure binding ligands as epigenetic modifiers with anti cancer effects |
| topic | epigenetics G4-interacting proteins dietary G4 structure-binding molecules histones chromatin replication |
| url | https://www.mdpi.com/1420-3049/24/3/582 |
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