Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease
Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes and is a chronic progressive condition. It is also a common cause of end-stage renal disease (ESRD), which is characterized by proteinuria or a progressive decline in the glomerular filtration rate. Due to their depende...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1257430/full |
| _version_ | 1797693180692398080 |
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| author | Shengjie Li Shanshan Zheng Jiao Li Jiao Li Sen Lin Hao Li Ping Wang Ping Wang Ping Wang Ping Chen Ping Chen Ping Chen Chaoqun Ma Yipeng Liu Yipeng Liu Yipeng Liu |
| author_facet | Shengjie Li Shanshan Zheng Jiao Li Jiao Li Sen Lin Hao Li Ping Wang Ping Wang Ping Wang Ping Chen Ping Chen Ping Chen Chaoqun Ma Yipeng Liu Yipeng Liu Yipeng Liu |
| author_sort | Shengjie Li |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes and is a chronic progressive condition. It is also a common cause of end-stage renal disease (ESRD), which is characterized by proteinuria or a progressive decline in the glomerular filtration rate. Due to their dependence on high-energy and aerobic metabolism, renal tubules are more susceptible to the metabolic disturbances associated with DKD, leading to inflammation and fibrosis. Consequently, tubular injury has become a recent research focus, and significant advancements have been made in studying the role of extracellular vesicles in DKD-associated tubular injury. This review aimed to elucidate the mechanisms and potential applications of different types of extracellular vesicles in tubular injury in DKD to provide new insights for the prevention and treatment of DKD. |
| first_indexed | 2024-03-12T02:39:50Z |
| format | Article |
| id | doaj.art-facfeecb72224a1bbc2550af09e2cd26 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T02:39:50Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-facfeecb72224a1bbc2550af09e2cd262023-09-04T09:06:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-09-011410.3389/fendo.2023.12574301257430Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney diseaseShengjie Li0Shanshan Zheng1Jiao Li2Jiao Li3Sen Lin4Hao Li5Ping Wang6Ping Wang7Ping Wang8Ping Chen9Ping Chen10Ping Chen11Chaoqun Ma12Yipeng Liu13Yipeng Liu14Yipeng Liu15Department of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Nephrology, Binzhou People’s Hospital Affiliated to Shandong First Medical University, Binzhou, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, ChinaNephrology Research Institute of Shandong Province, Jinan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, ChinaNephrology Research Institute of Shandong Province, Jinan, ChinaDepartment of Emergency Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, ChinaNephrology Research Institute of Shandong Province, Jinan, ChinaDiabetic kidney disease (DKD) is a severe microvascular complication of diabetes and is a chronic progressive condition. It is also a common cause of end-stage renal disease (ESRD), which is characterized by proteinuria or a progressive decline in the glomerular filtration rate. Due to their dependence on high-energy and aerobic metabolism, renal tubules are more susceptible to the metabolic disturbances associated with DKD, leading to inflammation and fibrosis. Consequently, tubular injury has become a recent research focus, and significant advancements have been made in studying the role of extracellular vesicles in DKD-associated tubular injury. This review aimed to elucidate the mechanisms and potential applications of different types of extracellular vesicles in tubular injury in DKD to provide new insights for the prevention and treatment of DKD.https://www.frontiersin.org/articles/10.3389/fendo.2023.1257430/fulldiabetic kidney diseaserenal tubular injuryextracellular vesiclesexosomesmiRNA |
| spellingShingle | Shengjie Li Shanshan Zheng Jiao Li Jiao Li Sen Lin Hao Li Ping Wang Ping Wang Ping Wang Ping Chen Ping Chen Ping Chen Chaoqun Ma Yipeng Liu Yipeng Liu Yipeng Liu Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease Frontiers in Endocrinology diabetic kidney disease renal tubular injury extracellular vesicles exosomes miRNA |
| title | Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease |
| title_full | Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease |
| title_fullStr | Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease |
| title_full_unstemmed | Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease |
| title_short | Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease |
| title_sort | research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease |
| topic | diabetic kidney disease renal tubular injury extracellular vesicles exosomes miRNA |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1257430/full |
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