Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells

Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells

We performed a detailed investigation of the uptake of sulfobromophthalein (BSP) from the apical membrane of Caco-2 cells, which is a substrate for organic anion transporting polypeptides (OATPs), and calculated the kinetic parameters of BSP uptake as follows: Km = 13.9 ± 1.3 μM, Vmax = 1.15 ± 0.07 ...

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Bibliographic Details
Main Authors:	Osamu Kimura, Yukiko Fujii, Koichi Haraguchi, Yoshihisa Kato, Chiho Ohta, Nobuyuki Koga, Tetsuya Endo
Format:	Article
Language:	English
Published:	Elsevier 2020-12-01
Series:	Biochemistry and Biophysics Reports
Subjects:	Perfluoroalkyl carboxylic acids (PFCAs) Sulfobromophthalein (BSP) Intestinal absorption Organic anion transport polypeptides (OATPs) Caco-2 cells
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405580820301175

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