From Structure to Function: Understanding Synthetic Conditions in Relation to Magnetic Properties of Hybrid Pd/Fe-Oxide Nanoparticles
Heterostructured magnetic nanoparticles show great potential for numerous applications in biomedicine due to their ability to express multiple functionalities in a single structure. Magnetic properties are generally determined by the morphological characteristics of nanoparticles, such as the size/s...
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MDPI AG
2022-10-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/20/3649 |
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| author | Alexandra Maier Rogier van Oossanen Gerard C. van Rhoon Jean-Philippe Pignol Iulian Dugulan Antonia G. Denkova Kristina Djanashvili |
| author_facet | Alexandra Maier Rogier van Oossanen Gerard C. van Rhoon Jean-Philippe Pignol Iulian Dugulan Antonia G. Denkova Kristina Djanashvili |
| author_sort | Alexandra Maier |
| collection | DOAJ |
| description | Heterostructured magnetic nanoparticles show great potential for numerous applications in biomedicine due to their ability to express multiple functionalities in a single structure. Magnetic properties are generally determined by the morphological characteristics of nanoparticles, such as the size/shape, and composition of the nanocrystals. These in turn are highly dependent on the synthetic conditions applied. Additionally, incorporation of a non-magnetic heterometal influences the final magnetic behavior. Therefore, construction of multifunctional hybrid nanoparticles with preserved magnetic properties represents a certain nanotechnological challenge. Here, we focus on palladium/iron oxide nanoparticles designed for combined brachytherapy, the internal form of radiotherapy, and MRI-guided hyperthermia of tumors. The choice of palladium forming the nanoparticle core is envisioned for the eventual radiolabeling with <sup>103</sup>Pd to enable the combination of hyperthermia with brachytherapy, the latter being beyond the scope of the present study. At this stage, we investigated the synthetic mechanisms and their effects on the final magnetic properties of the hybrid nanoparticles. Thermal decomposition was applied for the synthesis of Pd/Fe-oxide nanoparticles via both, one-pot and seed-mediated processes. The latter method was found to provide better control over morphology of the nanoparticles and was therefore examined closely by varying reaction conditions. This resulted in several batches of Pd/Fe-oxide nanoparticles, whose magnetic properties were evaluated, revealing the most relevant synthetic parameters leading to promising performance in hyperthermia and MRI. |
| first_indexed | 2024-03-09T19:40:59Z |
| format | Article |
| id | doaj.art-fad0b75458ac4968957f8b38495accb2 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T19:40:59Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-fad0b75458ac4968957f8b38495accb22023-11-24T01:41:04ZengMDPI AGNanomaterials2079-49912022-10-011220364910.3390/nano12203649From Structure to Function: Understanding Synthetic Conditions in Relation to Magnetic Properties of Hybrid Pd/Fe-Oxide NanoparticlesAlexandra Maier0Rogier van Oossanen1Gerard C. van Rhoon2Jean-Philippe Pignol3Iulian Dugulan4Antonia G. Denkova5Kristina Djanashvili6Department of Biotechnology, Delft University of Technology, Van Der Maasweg 9, 2629 HZ Delft, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, 3008 AE Rotterdam, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, 3008 AE Rotterdam, The NetherlandsDepartment of Physics and Atmospheric Sciences, Dalhousie University, Sir James Dunn Bldg., Halifax, NS B3H 4J5, CanadaDepartment of Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The NetherlandsDepartment of Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The NetherlandsDepartment of Biotechnology, Delft University of Technology, Van Der Maasweg 9, 2629 HZ Delft, The NetherlandsHeterostructured magnetic nanoparticles show great potential for numerous applications in biomedicine due to their ability to express multiple functionalities in a single structure. Magnetic properties are generally determined by the morphological characteristics of nanoparticles, such as the size/shape, and composition of the nanocrystals. These in turn are highly dependent on the synthetic conditions applied. Additionally, incorporation of a non-magnetic heterometal influences the final magnetic behavior. Therefore, construction of multifunctional hybrid nanoparticles with preserved magnetic properties represents a certain nanotechnological challenge. Here, we focus on palladium/iron oxide nanoparticles designed for combined brachytherapy, the internal form of radiotherapy, and MRI-guided hyperthermia of tumors. The choice of palladium forming the nanoparticle core is envisioned for the eventual radiolabeling with <sup>103</sup>Pd to enable the combination of hyperthermia with brachytherapy, the latter being beyond the scope of the present study. At this stage, we investigated the synthetic mechanisms and their effects on the final magnetic properties of the hybrid nanoparticles. Thermal decomposition was applied for the synthesis of Pd/Fe-oxide nanoparticles via both, one-pot and seed-mediated processes. The latter method was found to provide better control over morphology of the nanoparticles and was therefore examined closely by varying reaction conditions. This resulted in several batches of Pd/Fe-oxide nanoparticles, whose magnetic properties were evaluated, revealing the most relevant synthetic parameters leading to promising performance in hyperthermia and MRI.https://www.mdpi.com/2079-4991/12/20/3649hybrid nanoparticlesiron oxidepalladiumthermal decompositionmagnetizationsuperparamagnetism |
| spellingShingle | Alexandra Maier Rogier van Oossanen Gerard C. van Rhoon Jean-Philippe Pignol Iulian Dugulan Antonia G. Denkova Kristina Djanashvili From Structure to Function: Understanding Synthetic Conditions in Relation to Magnetic Properties of Hybrid Pd/Fe-Oxide Nanoparticles Nanomaterials hybrid nanoparticles iron oxide palladium thermal decomposition magnetization superparamagnetism |
| title | From Structure to Function: Understanding Synthetic Conditions in Relation to Magnetic Properties of Hybrid Pd/Fe-Oxide Nanoparticles |
| title_full | From Structure to Function: Understanding Synthetic Conditions in Relation to Magnetic Properties of Hybrid Pd/Fe-Oxide Nanoparticles |
| title_fullStr | From Structure to Function: Understanding Synthetic Conditions in Relation to Magnetic Properties of Hybrid Pd/Fe-Oxide Nanoparticles |
| title_full_unstemmed | From Structure to Function: Understanding Synthetic Conditions in Relation to Magnetic Properties of Hybrid Pd/Fe-Oxide Nanoparticles |
| title_short | From Structure to Function: Understanding Synthetic Conditions in Relation to Magnetic Properties of Hybrid Pd/Fe-Oxide Nanoparticles |
| title_sort | from structure to function understanding synthetic conditions in relation to magnetic properties of hybrid pd fe oxide nanoparticles |
| topic | hybrid nanoparticles iron oxide palladium thermal decomposition magnetization superparamagnetism |
| url | https://www.mdpi.com/2079-4991/12/20/3649 |
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