Current Understanding of Long-Term Cognitive Impairment After Sepsis
Sepsis is recognized as a life-threatening multi-organ dysfunction resulting from a dysregulated host response to infection. Although the incidence and mortality of sepsis decrease significantly due to timely implementation of anti-infective and support therapies, accumulating evidence suggests that...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.855006/full |
| _version_ | 1818028421208342528 |
|---|---|
| author | Ying Li Muhuo Ji Jianjun Yang |
| author_facet | Ying Li Muhuo Ji Jianjun Yang |
| author_sort | Ying Li |
| collection | DOAJ |
| description | Sepsis is recognized as a life-threatening multi-organ dysfunction resulting from a dysregulated host response to infection. Although the incidence and mortality of sepsis decrease significantly due to timely implementation of anti-infective and support therapies, accumulating evidence suggests that a great proportion of survivors suffer from long-term cognitive impairment after hospital discharge, leading to decreased life quality and substantial caregiving burdens for family members. Several mechanisms have been proposed for long-term cognitive impairment after sepsis, which are not mutually exclusive, including blood-brain barrier disruption, neuroinflammation, neurotransmitter dysfunction, and neuronal loss. Targeting these critical processes might be effective in preventing and treating long-term cognitive impairment. However, future in-depth studies are required to facilitate preventive and/or treatment strategies for long-term cognitive impairment after sepsis. |
| first_indexed | 2024-12-10T05:03:31Z |
| format | Article |
| id | doaj.art-fad2cafdf4fc458f8b38c94db67a86d4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T05:03:31Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fad2cafdf4fc458f8b38c94db67a86d42022-12-22T02:01:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.855006855006Current Understanding of Long-Term Cognitive Impairment After SepsisYing Li0Muhuo Ji1Jianjun Yang2Department of Anesthesiology, Jiangyin Hospital, Affiliated to Southeast University Medical School, Jiangyin, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaSepsis is recognized as a life-threatening multi-organ dysfunction resulting from a dysregulated host response to infection. Although the incidence and mortality of sepsis decrease significantly due to timely implementation of anti-infective and support therapies, accumulating evidence suggests that a great proportion of survivors suffer from long-term cognitive impairment after hospital discharge, leading to decreased life quality and substantial caregiving burdens for family members. Several mechanisms have been proposed for long-term cognitive impairment after sepsis, which are not mutually exclusive, including blood-brain barrier disruption, neuroinflammation, neurotransmitter dysfunction, and neuronal loss. Targeting these critical processes might be effective in preventing and treating long-term cognitive impairment. However, future in-depth studies are required to facilitate preventive and/or treatment strategies for long-term cognitive impairment after sepsis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.855006/fullsepsiscognitive impairmentBBB dysregulationneuroinflammationneurotransmitter dysfunctionneuronal loss |
| spellingShingle | Ying Li Muhuo Ji Jianjun Yang Current Understanding of Long-Term Cognitive Impairment After Sepsis Frontiers in Immunology sepsis cognitive impairment BBB dysregulation neuroinflammation neurotransmitter dysfunction neuronal loss |
| title | Current Understanding of Long-Term Cognitive Impairment After Sepsis |
| title_full | Current Understanding of Long-Term Cognitive Impairment After Sepsis |
| title_fullStr | Current Understanding of Long-Term Cognitive Impairment After Sepsis |
| title_full_unstemmed | Current Understanding of Long-Term Cognitive Impairment After Sepsis |
| title_short | Current Understanding of Long-Term Cognitive Impairment After Sepsis |
| title_sort | current understanding of long term cognitive impairment after sepsis |
| topic | sepsis cognitive impairment BBB dysregulation neuroinflammation neurotransmitter dysfunction neuronal loss |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.855006/full |
| work_keys_str_mv | AT yingli currentunderstandingoflongtermcognitiveimpairmentaftersepsis AT muhuoji currentunderstandingoflongtermcognitiveimpairmentaftersepsis AT jianjunyang currentunderstandingoflongtermcognitiveimpairmentaftersepsis |