Proliferation PET/CT Imaging of Salivary Gland Tumor
Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/11/2065 |
| _version_ | 1797510694251266048 |
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| author | Ryogo Minamimoto |
| author_facet | Ryogo Minamimoto |
| author_sort | Ryogo Minamimoto |
| collection | DOAJ |
| description | Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphic adenomas usually show increased FDG uptake, with no statistically significant difference in standardized uptake value (SUV) compared with malignant salivary gland tumors. Here, we discuss 4′-[methyl-11C]-thiothymidine (4DST) PET, which provides cell proliferation imaging capable of demonstrating intense uptake in parotid carcinoma and Warthin’s tumor, but no uptake in parotid pleomorphic adenoma. This is the first report of the potential of proliferation PET/ computed tomography (CT) imaging for characterizing salivary gland tumors based on the molecular pathogenesis of the tumor. |
| first_indexed | 2024-03-10T05:34:58Z |
| format | Article |
| id | doaj.art-fad3d8eca6e346fe9975a3a895069a53 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T05:34:58Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-fad3d8eca6e346fe9975a3a895069a532023-11-22T23:01:51ZengMDPI AGDiagnostics2075-44182021-11-011111206510.3390/diagnostics11112065Proliferation PET/CT Imaging of Salivary Gland TumorRyogo Minamimoto0National Center for Global Health and Medicine, Department of Radiology, Division of Nuclear Medicine, Tokyo 162-8655, JapanSalivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphic adenomas usually show increased FDG uptake, with no statistically significant difference in standardized uptake value (SUV) compared with malignant salivary gland tumors. Here, we discuss 4′-[methyl-11C]-thiothymidine (4DST) PET, which provides cell proliferation imaging capable of demonstrating intense uptake in parotid carcinoma and Warthin’s tumor, but no uptake in parotid pleomorphic adenoma. This is the first report of the potential of proliferation PET/ computed tomography (CT) imaging for characterizing salivary gland tumors based on the molecular pathogenesis of the tumor.https://www.mdpi.com/2075-4418/11/11/20654DST PET/CTcell proliferation imagingFDG PET/CTsalivary gland tumorpleomorphic adenomaWarthin’s tumor |
| spellingShingle | Ryogo Minamimoto Proliferation PET/CT Imaging of Salivary Gland Tumor Diagnostics 4DST PET/CT cell proliferation imaging FDG PET/CT salivary gland tumor pleomorphic adenoma Warthin’s tumor |
| title | Proliferation PET/CT Imaging of Salivary Gland Tumor |
| title_full | Proliferation PET/CT Imaging of Salivary Gland Tumor |
| title_fullStr | Proliferation PET/CT Imaging of Salivary Gland Tumor |
| title_full_unstemmed | Proliferation PET/CT Imaging of Salivary Gland Tumor |
| title_short | Proliferation PET/CT Imaging of Salivary Gland Tumor |
| title_sort | proliferation pet ct imaging of salivary gland tumor |
| topic | 4DST PET/CT cell proliferation imaging FDG PET/CT salivary gland tumor pleomorphic adenoma Warthin’s tumor |
| url | https://www.mdpi.com/2075-4418/11/11/2065 |
| work_keys_str_mv | AT ryogominamimoto proliferationpetctimagingofsalivaryglandtumor |