Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials
Vitamin D supplementation and its impact on immunoregulation are widely investigated. We aimed to assess the prevention and treatment efficiency of vitamin D supplementation in the context of coronavirus disease 2019 (COVID-19) and any disease-related complications. For this systematic review and me...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023903/full |
| _version_ | 1811256982813802496 |
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| author | Lara S. Kümmel Hanna Krumbein Paraskevi C. Fragkou Ben L. Hünerbein Rieke Reiter Konstantinos A. Papathanasiou Clemens Thölken Scott T. Weiss Harald Renz Chrysanthi Skevaki |
| author_facet | Lara S. Kümmel Hanna Krumbein Paraskevi C. Fragkou Ben L. Hünerbein Rieke Reiter Konstantinos A. Papathanasiou Clemens Thölken Scott T. Weiss Harald Renz Chrysanthi Skevaki |
| author_sort | Lara S. Kümmel |
| collection | DOAJ |
| description | Vitamin D supplementation and its impact on immunoregulation are widely investigated. We aimed to assess the prevention and treatment efficiency of vitamin D supplementation in the context of coronavirus disease 2019 (COVID-19) and any disease-related complications. For this systematic review and meta-analysis, we searched databases (PubMed, Embase, Scopus, Web of Science, The Cochrane Library, medRxiv, Cochrane COVID-19 Study Register, and ClinicalTrial.gov) for studies published between 1 November 2019 and 17 September 2021. We considered randomized trials (RCTs) as potentially eligible when patients were tested for SARS-CoV-2 infection and received vitamin D supplementation versus a placebo or standard-of-care control. A random-effects model was implemented to obtain pooled odds ratios for the effect of vitamin D supplementation on the main outcome of mortality as well as clinical outcomes. We identified a total of 5,733 articles, of which eight RCTs (657 patients) met the eligibility criteria. Although no statistically significant effects were reached, the use of vitamin D supplementation showed a trend for reduced mortality [odds ratio (OR) 0.74, 95% confidence interval (CI) 0.32–1.71, p = 0.48] compared with the control group, with even stronger effects, when vitamin D was administered repeatedly (OR 0.33, 95% CI 0.1–1.14). The mean difference for the length of hospitalization was −0.28 (95% CI −0.60 to 0.04), and the ORs were 0.41 (95% CI 0.15–1.12) and 0.52 (95% CI 0.27–1.02) for ICU admission and mechanical ventilation, respectively. In conclusion, vitamin D supplementation did not improve the clinical outcomes in COVID-19 patients, but trends of beneficial effects were observed. Further investigations are required, especially studies focusing on the daily administration of vitamin D. |
| first_indexed | 2024-04-12T17:49:31Z |
| format | Article |
| id | doaj.art-fad40390dd1b46d4a276d690f4e165d6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T17:49:31Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fad40390dd1b46d4a276d690f4e165d62022-12-22T03:22:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.10239031023903Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trialsLara S. Kümmel0Hanna Krumbein1Paraskevi C. Fragkou2Ben L. Hünerbein3Rieke Reiter4Konstantinos A. Papathanasiou5Clemens Thölken6Scott T. Weiss7Harald Renz8Chrysanthi Skevaki9Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UKGMLC), Philipps Universität Marburg, German Center for Lung Research/ Deutsches Zentrum für Lungenforschung (DZL) Marburg, Marburg, GermanyInstitute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UKGMLC), Philipps Universität Marburg, German Center for Lung Research/ Deutsches Zentrum für Lungenforschung (DZL) Marburg, Marburg, GermanyFirst Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, Medical School of Athens, National and Kapodistrian University of Athens, Athens, GreeceInstitute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UKGMLC), Philipps Universität Marburg, German Center for Lung Research/ Deutsches Zentrum für Lungenforschung (DZL) Marburg, Marburg, GermanyInstitute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UKGMLC), Philipps Universität Marburg, German Center for Lung Research/ Deutsches Zentrum für Lungenforschung (DZL) Marburg, Marburg, GermanyMedical School, National and Kapodistrian University of Athens, Athens, GreeceInstitute of Medical Bioinformatics and Biostatistics, Medical Faculty, Philipps University of Marburg, Marburg, GermanyChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesInstitute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UKGMLC), Philipps Universität Marburg, German Center for Lung Research/ Deutsches Zentrum für Lungenforschung (DZL) Marburg, Marburg, GermanyInstitute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UKGMLC), Philipps Universität Marburg, German Center for Lung Research/ Deutsches Zentrum für Lungenforschung (DZL) Marburg, Marburg, GermanyVitamin D supplementation and its impact on immunoregulation are widely investigated. We aimed to assess the prevention and treatment efficiency of vitamin D supplementation in the context of coronavirus disease 2019 (COVID-19) and any disease-related complications. For this systematic review and meta-analysis, we searched databases (PubMed, Embase, Scopus, Web of Science, The Cochrane Library, medRxiv, Cochrane COVID-19 Study Register, and ClinicalTrial.gov) for studies published between 1 November 2019 and 17 September 2021. We considered randomized trials (RCTs) as potentially eligible when patients were tested for SARS-CoV-2 infection and received vitamin D supplementation versus a placebo or standard-of-care control. A random-effects model was implemented to obtain pooled odds ratios for the effect of vitamin D supplementation on the main outcome of mortality as well as clinical outcomes. We identified a total of 5,733 articles, of which eight RCTs (657 patients) met the eligibility criteria. Although no statistically significant effects were reached, the use of vitamin D supplementation showed a trend for reduced mortality [odds ratio (OR) 0.74, 95% confidence interval (CI) 0.32–1.71, p = 0.48] compared with the control group, with even stronger effects, when vitamin D was administered repeatedly (OR 0.33, 95% CI 0.1–1.14). The mean difference for the length of hospitalization was −0.28 (95% CI −0.60 to 0.04), and the ORs were 0.41 (95% CI 0.15–1.12) and 0.52 (95% CI 0.27–1.02) for ICU admission and mechanical ventilation, respectively. In conclusion, vitamin D supplementation did not improve the clinical outcomes in COVID-19 patients, but trends of beneficial effects were observed. Further investigations are required, especially studies focusing on the daily administration of vitamin D.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023903/fullvitamin DSARS-CoV-2COVID-19systematic reviewmeta-analysis |
| spellingShingle | Lara S. Kümmel Hanna Krumbein Paraskevi C. Fragkou Ben L. Hünerbein Rieke Reiter Konstantinos A. Papathanasiou Clemens Thölken Scott T. Weiss Harald Renz Chrysanthi Skevaki Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials Frontiers in Immunology vitamin D SARS-CoV-2 COVID-19 systematic review meta-analysis |
| title | Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
| title_full | Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
| title_short | Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
| title_sort | vitamin d supplementation for the treatment of covid 19 a systematic review and meta analysis of randomized controlled trials |
| topic | vitamin D SARS-CoV-2 COVID-19 systematic review meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023903/full |
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