DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway

DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway

Abstract CDK4/6 are important regulators of cell cycle and their inhibitors have been approved as anti-cancer drugs. Here, we report a STING-dependent anti-tumor immune mechanism responsible for tumor suppression by CDK4/6 blockade. Clinical datasets show that in human tissues, CDK4 and CDK6 are ove...

Full description

Bibliographic Details
Main Authors: Huimin Fan, Wancheng Liu, Yanqiong Zeng, Ying Zhou, Meiling Gao, Liping Yang, Hao Liu, Yueyue Shi, Lili Li, Jiayuan Ma, Jiayin Ruan, Ruyun Cao, Xiaoxia Jin, Jian Chen, Genhong Cheng, Heng Yang
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05412-x

Internet

https://doi.org/10.1038/s42003-023-05412-x

Similar Items