Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis
AIM: To compare the thickness of the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) among patients with various forms of optic neuritis (ON) and to identify whether any particular parameters or their thinning pattern can be used to distinguish the type...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2018-10-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2018/10/20181012.pdf |
| _version_ | 1828346098416091136 |
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| author | Nattapong Mekhasingharak Poramaet Laowanapiban Sasitorn Siritho Chanjira Satukijchai Naraporn Prayoonwiwat Jiraporn Jitprapaikulsan Niphon Chirapapaisan Siriraj Neuroimmunology Research Group |
| author_facet | Nattapong Mekhasingharak Poramaet Laowanapiban Sasitorn Siritho Chanjira Satukijchai Naraporn Prayoonwiwat Jiraporn Jitprapaikulsan Niphon Chirapapaisan Siriraj Neuroimmunology Research Group |
| author_sort | Nattapong Mekhasingharak |
| collection | DOAJ |
| description | AIM: To compare the thickness of the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) among patients with various forms of optic neuritis (ON) and to identify whether any particular parameters or their thinning pattern can be used to distinguish the type of ON.
METHODS: This prospective study was conducted at the Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Thailand, between January, 2015 and December, 2016. We enlisted patients over 18 years of age with history of ON and categorized patients into 4 groups: 1) aquaporin 4 antibodies (AQP4-IgG) positive; 2) multiple sclerosis (MS); 3) myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) positive; 4) idiopathic-ON patients. Healthy controls were also included during the same study period. All patients underwent complete ophthalmological examination and spectral domain optical coherence tomography (OCT) imaging to analyze RNFL and GCIPL thickness after at least 3mo since the last episode of acute ON. The generalized estimating equation (GEE) models were used to compare the data amongst ON groups.
RESULTS: Among 87 previous ON eyes from 57 patients (43 AQP4-IgG+ON, 17 MS-ON, 8 MOG-IgG+ON, and 19 idiopathic-ON), mean logMAR visual acuity of AQP4-IgG+ON, MS-ON, MOG-IgG+ON, and idiopathic-ON groups was 0.76±0.88, 0.12±0.25, 0.39±0.31, and 0.75±1.08, respectively. Average, superior, and inferior RNFL were significantly reduced in AQP4-IgG+ON, MOG-IgG+ON and idiopathic-ON eyes, relative to those of MS-ON. Differences were not statistically significant for RNFL or GCIPL between the AQP4-IgG+ON and MOG-IgG+ON groups, whereas visual acuity in MOG-IgG+ON was slightly, but not significantly, better (0.39 vs 0.76). Although RNFL thickness in MOG-IgG+ON was significantly reduced as compared to MS-ON, mean visual acuity and GCIPL were not different.
CONCLUSION: Thinning of superior and inferior quadrants of RNFL are more commonly seen in MOG-IgG+ON and AQP4-IgG+ON. Long term visual acuity in MOG-IgG+ON is often better than AQP4-IgG+ON, whereas the structural change from OCT is comparable. |
| first_indexed | 2024-04-14T00:21:29Z |
| format | Article |
| id | doaj.art-fad64d8df29043dd87c7938662f7328b |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-14T00:21:29Z |
| publishDate | 2018-10-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-fad64d8df29043dd87c7938662f7328b2022-12-22T02:22:57ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982018-10-0111101649165610.18240/ijo.2018.10.12Optical coherence tomography in central nervous system demyelinating diseases related optic neuritisNattapong Mekhasingharak0Poramaet Laowanapiban1Sasitorn Siritho2Chanjira Satukijchai3Naraporn Prayoonwiwat4Jiraporn Jitprapaikulsan5Niphon Chirapapaisan6Siriraj Neuroimmunology Research Group7Department of Ophthalmology, Naresuan University Hospital, Naresuan University, Phitsanulok 65000, ThailandDepartment of Ophthalmology, Mettapracharak Hospital, Nakhon Pathom 73110, ThailandDivision of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand; Bumrungrad International Hospital, Bangkok 10110, ThailandDivision of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand; Bangkok Hospital Headquarters, Bangkok 10310, ThailandDivision of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Ophthalmology, Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandundefinedAIM: To compare the thickness of the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) among patients with various forms of optic neuritis (ON) and to identify whether any particular parameters or their thinning pattern can be used to distinguish the type of ON. METHODS: This prospective study was conducted at the Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Thailand, between January, 2015 and December, 2016. We enlisted patients over 18 years of age with history of ON and categorized patients into 4 groups: 1) aquaporin 4 antibodies (AQP4-IgG) positive; 2) multiple sclerosis (MS); 3) myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) positive; 4) idiopathic-ON patients. Healthy controls were also included during the same study period. All patients underwent complete ophthalmological examination and spectral domain optical coherence tomography (OCT) imaging to analyze RNFL and GCIPL thickness after at least 3mo since the last episode of acute ON. The generalized estimating equation (GEE) models were used to compare the data amongst ON groups. RESULTS: Among 87 previous ON eyes from 57 patients (43 AQP4-IgG+ON, 17 MS-ON, 8 MOG-IgG+ON, and 19 idiopathic-ON), mean logMAR visual acuity of AQP4-IgG+ON, MS-ON, MOG-IgG+ON, and idiopathic-ON groups was 0.76±0.88, 0.12±0.25, 0.39±0.31, and 0.75±1.08, respectively. Average, superior, and inferior RNFL were significantly reduced in AQP4-IgG+ON, MOG-IgG+ON and idiopathic-ON eyes, relative to those of MS-ON. Differences were not statistically significant for RNFL or GCIPL between the AQP4-IgG+ON and MOG-IgG+ON groups, whereas visual acuity in MOG-IgG+ON was slightly, but not significantly, better (0.39 vs 0.76). Although RNFL thickness in MOG-IgG+ON was significantly reduced as compared to MS-ON, mean visual acuity and GCIPL were not different. CONCLUSION: Thinning of superior and inferior quadrants of RNFL are more commonly seen in MOG-IgG+ON and AQP4-IgG+ON. Long term visual acuity in MOG-IgG+ON is often better than AQP4-IgG+ON, whereas the structural change from OCT is comparable.http://www.ijo.cn/en_publish/2018/10/20181012.pdfoptical coherence tomographyneuromyelitis opticamultiple sclerosismyelin oligodendrocyte glycoprotein antibodyoptic neuritis |
| spellingShingle | Nattapong Mekhasingharak Poramaet Laowanapiban Sasitorn Siritho Chanjira Satukijchai Naraporn Prayoonwiwat Jiraporn Jitprapaikulsan Niphon Chirapapaisan Siriraj Neuroimmunology Research Group Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis International Journal of Ophthalmology optical coherence tomography neuromyelitis optica multiple sclerosis myelin oligodendrocyte glycoprotein antibody optic neuritis |
| title | Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis |
| title_full | Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis |
| title_fullStr | Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis |
| title_full_unstemmed | Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis |
| title_short | Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis |
| title_sort | optical coherence tomography in central nervous system demyelinating diseases related optic neuritis |
| topic | optical coherence tomography neuromyelitis optica multiple sclerosis myelin oligodendrocyte glycoprotein antibody optic neuritis |
| url | http://www.ijo.cn/en_publish/2018/10/20181012.pdf |
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