Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival

Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival

<p>Abstract</p> <p>Background</p> <p>The mitotic Aurora-A kinase exerts crucial functions in maintaining mitotic fidelity. As a bona fide oncoprotein, Aurora-A aberrant overexpression leads to oncogenic transformation. Yet, the mechanisms by which Aurora-A enhances canc...

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Bibliographic Details
Main Authors: Li Ming-wei, Zhao Yan, Long Zi-jie, Wang Li-hui, Li Chuan-xing, Xia Liang-ping, Pan Chao-bin, Guan Zhong, Yan Min, Yao Jin-e, Zheng Fei-meng, Xu Jie, Lin Dong-jun, Liu Quentin
Format: Article
Language:English
Published: BMC 2009-11-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/8/1/95

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