Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

The immunological synapse allows antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells, which ultimately shape the immune response. The relative effect of stimulatory and inhibitory signals is influenced by the activation state of the APC, which is determ...

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Bibliographic Details
Main Authors: Michael C Kiritsy, Katelyn McCann, Daniel Mott, Steven M Holland, Samuel M Behar, Christopher M Sassetti, Andrew J Olive
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
IFN gamma
APC function
complex I
PD-L1 regulation
mitochondrial respiration
immunometabolism
Online Access:https://elifesciences.org/articles/65109

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