Laser Sintering Approaches for Bone Tissue Engineering
The adoption of additive manufacturing (AM) techniques into the medical space has revolutionised tissue engineering. Depending upon the tissue type, specific AM approaches are capable of closely matching the physical and biological tissue attributes, to guide tissue regeneration. For hard tissue suc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/14/12/2336 |
| _version_ | 1797483104035667968 |
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| author | Jeremy N. DiNoro Naomi C. Paxton Jacob Skewes Zhilian Yue Philip M. Lewis Robert G. Thompson Stephen Beirne Maria A. Woodruff Gordon G. Wallace |
| author_facet | Jeremy N. DiNoro Naomi C. Paxton Jacob Skewes Zhilian Yue Philip M. Lewis Robert G. Thompson Stephen Beirne Maria A. Woodruff Gordon G. Wallace |
| author_sort | Jeremy N. DiNoro |
| collection | DOAJ |
| description | The adoption of additive manufacturing (AM) techniques into the medical space has revolutionised tissue engineering. Depending upon the tissue type, specific AM approaches are capable of closely matching the physical and biological tissue attributes, to guide tissue regeneration. For hard tissue such as bone, powder bed fusion (PBF) techniques have significant potential, as they are capable of fabricating materials that can match the mechanical requirements necessary to maintain bone functionality and support regeneration. This review focuses on the PBF techniques that utilize laser sintering for creating scaffolds for bone tissue engineering (BTE) applications. Optimal scaffold requirements are explained, ranging from material biocompatibility and bioactivity, to generating specific architectures to recapitulate the porosity, interconnectivity, and mechanical properties of native human bone. The main objective of the review is to outline the most common materials processed using PBF in the context of BTE; initially outlining the most common polymers, including polyamide, polycaprolactone, polyethylene, and polyetheretherketone. Subsequent sections investigate the use of metals and ceramics in similar systems for BTE applications. The last section explores how composite materials can be used. Within each material section, the benefits and shortcomings are outlined, including their mechanical and biological performance, as well as associated printing parameters. The framework provided can be applied to the development of new, novel materials or laser-based approaches to ultimately generate bone tissue analogues or for guiding bone regeneration. |
| first_indexed | 2024-03-09T22:43:07Z |
| format | Article |
| id | doaj.art-fadd24faaf084f96ac947edc16eec3c8 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T22:43:07Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-fadd24faaf084f96ac947edc16eec3c82023-11-23T18:36:13ZengMDPI AGPolymers2073-43602022-06-011412233610.3390/polym14122336Laser Sintering Approaches for Bone Tissue EngineeringJeremy N. DiNoro0Naomi C. Paxton1Jacob Skewes2Zhilian Yue3Philip M. Lewis4Robert G. Thompson5Stephen Beirne6Maria A. Woodruff7Gordon G. Wallace8ARC Centre of Excellence for Electromaterials Science, Innovation Campus, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, AustraliaAustralian Research Council Industrial Transformation Training Centre in Additive Biomanufacturing, Brisbane, QLD 4059, AustraliaCentre for Biomedical Technologies, Queensland University of Technology, Brisbane, QLD 4059, AustraliaARC Centre of Excellence for Electromaterials Science, Innovation Campus, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, AustraliaDepartment of Surgery, Faculty of Medicine, Nursing & Health Sciences, Central Clinical School, Monash University, Melbourne, VIC 3800, AustraliaAnatomics Pty. Ltd., Melbourne, VIC 3165, AustraliaARC Centre of Excellence for Electromaterials Science, Innovation Campus, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, AustraliaAustralian Research Council Industrial Transformation Training Centre in Additive Biomanufacturing, Brisbane, QLD 4059, AustraliaARC Centre of Excellence for Electromaterials Science, Innovation Campus, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, AustraliaThe adoption of additive manufacturing (AM) techniques into the medical space has revolutionised tissue engineering. Depending upon the tissue type, specific AM approaches are capable of closely matching the physical and biological tissue attributes, to guide tissue regeneration. For hard tissue such as bone, powder bed fusion (PBF) techniques have significant potential, as they are capable of fabricating materials that can match the mechanical requirements necessary to maintain bone functionality and support regeneration. This review focuses on the PBF techniques that utilize laser sintering for creating scaffolds for bone tissue engineering (BTE) applications. Optimal scaffold requirements are explained, ranging from material biocompatibility and bioactivity, to generating specific architectures to recapitulate the porosity, interconnectivity, and mechanical properties of native human bone. The main objective of the review is to outline the most common materials processed using PBF in the context of BTE; initially outlining the most common polymers, including polyamide, polycaprolactone, polyethylene, and polyetheretherketone. Subsequent sections investigate the use of metals and ceramics in similar systems for BTE applications. The last section explores how composite materials can be used. Within each material section, the benefits and shortcomings are outlined, including their mechanical and biological performance, as well as associated printing parameters. The framework provided can be applied to the development of new, novel materials or laser-based approaches to ultimately generate bone tissue analogues or for guiding bone regeneration.https://www.mdpi.com/2073-4360/14/12/23363D printingadditive manufacturingimplantssinteringpolymersbone regeneration |
| spellingShingle | Jeremy N. DiNoro Naomi C. Paxton Jacob Skewes Zhilian Yue Philip M. Lewis Robert G. Thompson Stephen Beirne Maria A. Woodruff Gordon G. Wallace Laser Sintering Approaches for Bone Tissue Engineering Polymers 3D printing additive manufacturing implants sintering polymers bone regeneration |
| title | Laser Sintering Approaches for Bone Tissue Engineering |
| title_full | Laser Sintering Approaches for Bone Tissue Engineering |
| title_fullStr | Laser Sintering Approaches for Bone Tissue Engineering |
| title_full_unstemmed | Laser Sintering Approaches for Bone Tissue Engineering |
| title_short | Laser Sintering Approaches for Bone Tissue Engineering |
| title_sort | laser sintering approaches for bone tissue engineering |
| topic | 3D printing additive manufacturing implants sintering polymers bone regeneration |
| url | https://www.mdpi.com/2073-4360/14/12/2336 |
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