The Clinical Manifestation of SARS-CoV-2 in Critically Ill Patients with <i>Klebsiella pneumoniae</i> NDM Hospitalized in the ICU of a Modular Hospital during the Third Wave of the Pandemic in Poland—An Observational Cohort Study
There is limited information on the clinical characteristics of critically ill patients infected with SARS-CoV-2 and <i>Klebsiella pneumoniae</i> NDM. The objective of this study was to describe such a group of patients hospitalised in the intensive care unit of a large academic hospital...
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MDPI AG
2022-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/5/1118 |
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| author | Aneta Guzek Zbigniew Rybicki Agnieszka Woźniak-Kosek Dariusz Tomaszewski |
| author_facet | Aneta Guzek Zbigniew Rybicki Agnieszka Woźniak-Kosek Dariusz Tomaszewski |
| author_sort | Aneta Guzek |
| collection | DOAJ |
| description | There is limited information on the clinical characteristics of critically ill patients infected with SARS-CoV-2 and <i>Klebsiella pneumoniae</i> NDM. The objective of this study was to describe such a group of patients hospitalised in the intensive care unit of a large academic hospital during the third wave of the COVID-19 pandemic in Poland. Between 1 March and 30 June 2021, 103 patients were hospitalised, of whom 23 (22.3%) were positive for <i>K. pneumoniae</i> NDM; 14 (61%) of those patients died. Their hospitalisation time varied between 9 and 47 days. Five of the 23 patients (21.7%) were otherwise healthy. In contrast, the others suffered from cardiovascular problems (11, 47.8%), obesity (6, 26.1%), diabetes (5, 21.7%), neurological problems (4, 17.4%), or kidney disease (1, 4.3%); 4 (17.4%) were heavy smokers, and 1 (4.3%) had a history of alcohol abuse. <i>K. pneumoniae</i> NDM was isolated from urine samples of all patients. In 17 patients (73.9%), it was also isolated from other sources: from the respiratory tract in 10 (43.8%), from the blood in 2 (8.7%), and the central venous catheter was contaminated in 1 case (4.3%). Fourteen of the patients (60.9%) were colonised <i>K. pneumoniae</i> NDM. In four patients (17.4%), bacterial and fungal coinfection occurred. In one case (4.4%), two fungal species, <i>Candida albicans</i> and <i>Candida glabrata</i>, were isolated simultaneously. The most frequently administered antimicrobial agent was colistin (60.9%), followed by meropenem (47.8%), vancomycin (47.8%), ceftriaxone (34.8%), linezolid (30.4%), piperacillin/tazobactam (30.4%), and trimethoprim/sulfamethoxazole (30.4%). Other less-frequently administered agents included amikacin, amoxicillin/clavulanate, tigecycline, ciprofloxacin, fosfomycin, clindamycin, and cloxacillin. Fluconazole was administered in 14 patients (60.7%) and micafungin was administered in 2 (8.7%). |
| first_indexed | 2024-03-10T03:03:26Z |
| format | Article |
| id | doaj.art-fadd758c9b0d478b8ab8aa58527d8cf8 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T03:03:26Z |
| publishDate | 2022-04-01 |
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| spelling | doaj.art-fadd758c9b0d478b8ab8aa58527d8cf82023-11-23T10:39:37ZengMDPI AGDiagnostics2075-44182022-04-01125111810.3390/diagnostics12051118The Clinical Manifestation of SARS-CoV-2 in Critically Ill Patients with <i>Klebsiella pneumoniae</i> NDM Hospitalized in the ICU of a Modular Hospital during the Third Wave of the Pandemic in Poland—An Observational Cohort StudyAneta Guzek0Zbigniew Rybicki1Agnieszka Woźniak-Kosek2Dariusz Tomaszewski3Department of Laboratory Diagnostics, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Anaesthesiology and Intensive Therapy, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Laboratory Diagnostics, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Anaesthesiology and Intensive Therapy, Military Institute of Aviation Medicine, 01-755 Warsaw, PolandThere is limited information on the clinical characteristics of critically ill patients infected with SARS-CoV-2 and <i>Klebsiella pneumoniae</i> NDM. The objective of this study was to describe such a group of patients hospitalised in the intensive care unit of a large academic hospital during the third wave of the COVID-19 pandemic in Poland. Between 1 March and 30 June 2021, 103 patients were hospitalised, of whom 23 (22.3%) were positive for <i>K. pneumoniae</i> NDM; 14 (61%) of those patients died. Their hospitalisation time varied between 9 and 47 days. Five of the 23 patients (21.7%) were otherwise healthy. In contrast, the others suffered from cardiovascular problems (11, 47.8%), obesity (6, 26.1%), diabetes (5, 21.7%), neurological problems (4, 17.4%), or kidney disease (1, 4.3%); 4 (17.4%) were heavy smokers, and 1 (4.3%) had a history of alcohol abuse. <i>K. pneumoniae</i> NDM was isolated from urine samples of all patients. In 17 patients (73.9%), it was also isolated from other sources: from the respiratory tract in 10 (43.8%), from the blood in 2 (8.7%), and the central venous catheter was contaminated in 1 case (4.3%). Fourteen of the patients (60.9%) were colonised <i>K. pneumoniae</i> NDM. In four patients (17.4%), bacterial and fungal coinfection occurred. In one case (4.4%), two fungal species, <i>Candida albicans</i> and <i>Candida glabrata</i>, were isolated simultaneously. The most frequently administered antimicrobial agent was colistin (60.9%), followed by meropenem (47.8%), vancomycin (47.8%), ceftriaxone (34.8%), linezolid (30.4%), piperacillin/tazobactam (30.4%), and trimethoprim/sulfamethoxazole (30.4%). Other less-frequently administered agents included amikacin, amoxicillin/clavulanate, tigecycline, ciprofloxacin, fosfomycin, clindamycin, and cloxacillin. Fluconazole was administered in 14 patients (60.7%) and micafungin was administered in 2 (8.7%).https://www.mdpi.com/2075-4418/12/5/1118COVID-19critically ill<i>Klebsiella pneumoniae</i> NDM |
| spellingShingle | Aneta Guzek Zbigniew Rybicki Agnieszka Woźniak-Kosek Dariusz Tomaszewski The Clinical Manifestation of SARS-CoV-2 in Critically Ill Patients with <i>Klebsiella pneumoniae</i> NDM Hospitalized in the ICU of a Modular Hospital during the Third Wave of the Pandemic in Poland—An Observational Cohort Study Diagnostics COVID-19 critically ill <i>Klebsiella pneumoniae</i> NDM |
| title | The Clinical Manifestation of SARS-CoV-2 in Critically Ill Patients with <i>Klebsiella pneumoniae</i> NDM Hospitalized in the ICU of a Modular Hospital during the Third Wave of the Pandemic in Poland—An Observational Cohort Study |
| title_full | The Clinical Manifestation of SARS-CoV-2 in Critically Ill Patients with <i>Klebsiella pneumoniae</i> NDM Hospitalized in the ICU of a Modular Hospital during the Third Wave of the Pandemic in Poland—An Observational Cohort Study |
| title_fullStr | The Clinical Manifestation of SARS-CoV-2 in Critically Ill Patients with <i>Klebsiella pneumoniae</i> NDM Hospitalized in the ICU of a Modular Hospital during the Third Wave of the Pandemic in Poland—An Observational Cohort Study |
| title_full_unstemmed | The Clinical Manifestation of SARS-CoV-2 in Critically Ill Patients with <i>Klebsiella pneumoniae</i> NDM Hospitalized in the ICU of a Modular Hospital during the Third Wave of the Pandemic in Poland—An Observational Cohort Study |
| title_short | The Clinical Manifestation of SARS-CoV-2 in Critically Ill Patients with <i>Klebsiella pneumoniae</i> NDM Hospitalized in the ICU of a Modular Hospital during the Third Wave of the Pandemic in Poland—An Observational Cohort Study |
| title_sort | clinical manifestation of sars cov 2 in critically ill patients with i klebsiella pneumoniae i ndm hospitalized in the icu of a modular hospital during the third wave of the pandemic in poland an observational cohort study |
| topic | COVID-19 critically ill <i>Klebsiella pneumoniae</i> NDM |
| url | https://www.mdpi.com/2075-4418/12/5/1118 |
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