Reconstructed Metabolic Network Models Predict Flux-Level Metabolic Reprogramming in Glioblastoma

Reconstructed Metabolic Network Models Predict Flux-Level Metabolic Reprogramming in Glioblastoma

Developments in genome scale metabolic modeling techniques and omics technologies have enabled the reconstruction of context-specific metabolic models. In this study, glioblastoma multiforme (GBM), one of the most common and aggressive malignant brain tumors, is investigated by mapping GBM gene expr...

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Bibliographic Details
Main Authors:	Emrah eOzcan, Tunahan eCakir
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-04-01
Series:	Frontiers in Neuroscience
Subjects:	aerobic glycolysis Constraint-based modeling Glutaminolysis OMICS data Tumor subtypes GBM-specific metabolic model
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00156/full

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