Summary of Dose-Response Modeling for Developmental Toxicity Studies
Developmental toxicity studies are an important area in the field of toxicology. Endpoints measured on fetuses include weight and indicators of death and malformation. Binary indicator measures are typically summed over the litter and a discrete distribution is assumed to model the number of adverse...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2008-10-01
|
| Series: | Dose-Response |
| Online Access: | https://doi.org/10.2203/dose-response.08-007.Hunt |
| _version_ | 1811331496182546432 |
|---|---|
| author | Daniel L. Hunt Shesh N. Rai Chin-Shang Li |
| author_facet | Daniel L. Hunt Shesh N. Rai Chin-Shang Li |
| author_sort | Daniel L. Hunt |
| collection | DOAJ |
| description | Developmental toxicity studies are an important area in the field of toxicology. Endpoints measured on fetuses include weight and indicators of death and malformation. Binary indicator measures are typically summed over the litter and a discrete distribution is assumed to model the number of adversely affected fetuses. Additionally, there is noticeable variation in the litter responses within dose groups that should be taken into account when modeling. Finally, the dose-response pattern in these studies exhibits a threshold effect. The threshold dose-response model is the default model for non-carcinogenic risk assessment, according to the USEPA, and is encouraged by the agency for the use in the risk assessment process. Two statistical models are proposed to estimate dose-response pattern of data from the developmental toxicity study: the threshold model and the spline model. The models were applied to two data sets. The advantages and disadvantages of these models, potential other models, and future research possibilities will be summarized. |
| first_indexed | 2024-04-13T16:21:25Z |
| format | Article |
| id | doaj.art-fadf30c737884bccbd2d0e7a77c44e24 |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-04-13T16:21:25Z |
| publishDate | 2008-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-fadf30c737884bccbd2d0e7a77c44e242022-12-22T02:39:56ZengSAGE PublishingDose-Response1559-32582008-10-01610.2203/dose-response.08-007.HuntSummary of Dose-Response Modeling for Developmental Toxicity StudiesDaniel L. HuntShesh N. RaiChin-Shang LiDevelopmental toxicity studies are an important area in the field of toxicology. Endpoints measured on fetuses include weight and indicators of death and malformation. Binary indicator measures are typically summed over the litter and a discrete distribution is assumed to model the number of adversely affected fetuses. Additionally, there is noticeable variation in the litter responses within dose groups that should be taken into account when modeling. Finally, the dose-response pattern in these studies exhibits a threshold effect. The threshold dose-response model is the default model for non-carcinogenic risk assessment, according to the USEPA, and is encouraged by the agency for the use in the risk assessment process. Two statistical models are proposed to estimate dose-response pattern of data from the developmental toxicity study: the threshold model and the spline model. The models were applied to two data sets. The advantages and disadvantages of these models, potential other models, and future research possibilities will be summarized.https://doi.org/10.2203/dose-response.08-007.Hunt |
| spellingShingle | Daniel L. Hunt Shesh N. Rai Chin-Shang Li Summary of Dose-Response Modeling for Developmental Toxicity Studies Dose-Response |
| title | Summary of Dose-Response Modeling for Developmental Toxicity Studies |
| title_full | Summary of Dose-Response Modeling for Developmental Toxicity Studies |
| title_fullStr | Summary of Dose-Response Modeling for Developmental Toxicity Studies |
| title_full_unstemmed | Summary of Dose-Response Modeling for Developmental Toxicity Studies |
| title_short | Summary of Dose-Response Modeling for Developmental Toxicity Studies |
| title_sort | summary of dose response modeling for developmental toxicity studies |
| url | https://doi.org/10.2203/dose-response.08-007.Hunt |
| work_keys_str_mv | AT daniellhunt summaryofdoseresponsemodelingfordevelopmentaltoxicitystudies AT sheshnrai summaryofdoseresponsemodelingfordevelopmentaltoxicitystudies AT chinshangli summaryofdoseresponsemodelingfordevelopmentaltoxicitystudies |