Isoflavone-Enriched Soybean Leaves (Glycine Max) Alleviate Cognitive Impairment Induced by Ovariectomy and Modulate PI3K/Akt Signaling in the Hippocampus of C57BL6 Mice
(1) Background: The estrogen decline during perimenopause can induce various disorders, including cognitive impairment. Phytoestrogens, such as isoflavones, lignans, and coumestans, have been tried as a popular alternative to avoid the side effects of conventional hormone replacement therapy, but th...
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| author | Dae Young Yoo Soonwoong Jung Jae Soon Kang Ji Hyeong Baek Ki Hun Park Dong Hoon Lee Sang Soo Kang Hyun Joon Kim |
| author_facet | Dae Young Yoo Soonwoong Jung Jae Soon Kang Ji Hyeong Baek Ki Hun Park Dong Hoon Lee Sang Soo Kang Hyun Joon Kim |
| author_sort | Dae Young Yoo |
| collection | DOAJ |
| description | (1) Background: The estrogen decline during perimenopause can induce various disorders, including cognitive impairment. Phytoestrogens, such as isoflavones, lignans, and coumestans, have been tried as a popular alternative to avoid the side effects of conventional hormone replacement therapy, but their exact mechanisms and risk are not fully elucidated. In this study, we investigated the effects of isoflavone-enriched soybean leaves (IESLs) on the cognitive impairment induced by ovariectomy in female mice. (2) Methods: Ovariectomy was performed at 9 weeks of age to mimic menopausal women, and the behavior tests for cognition were conducted 15 weeks after the first administration. IESLs were administered for 18 weeks. (3) Results: The present study showed the effects of IESLs on the cognitive function in the OVX (ovariectomized) mice. Ovariectomy markedly increased the body weight and fat accumulation in the liver and perirenal fat, but IESL treatment significantly inhibited them. In the behavioral tests, ovariectomy impaired cognitive functions, but administration of IESLs restored it. In addition, in the OVX mice, administration of IESLs restored decreased estrogen receptor (ER) β and PI3K/Akt expression in the hippocampus. (4) Conclusions: The positive effects of IESLs on cognitive functions may be closely related to the ER-mediated PI3/Akt signaling pathway in the hippocampus. |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:06:32Z |
| publishDate | 2022-11-01 |
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| series | Nutrients |
| spelling | doaj.art-fadfa834f92343038be523e4a5f0513a2023-11-24T09:30:33ZengMDPI AGNutrients2072-66432022-11-011422475310.3390/nu14224753Isoflavone-Enriched Soybean Leaves (Glycine Max) Alleviate Cognitive Impairment Induced by Ovariectomy and Modulate PI3K/Akt Signaling in the Hippocampus of C57BL6 MiceDae Young Yoo0Soonwoong Jung1Jae Soon Kang2Ji Hyeong Baek3Ki Hun Park4Dong Hoon Lee5Sang Soo Kang6Hyun Joon Kim7Department of Anatomy and Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaDepartment of Anatomy and Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaDepartment of Anatomy and Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaDepartment of Anatomy and Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaDivision of Applied Life Science (BK21 Plus), IALS, Gyeongsang National University, Jinju 52828, KoreaDepartment of Anatomy and Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaDepartment of Anatomy and Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaDepartment of Anatomy and Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea(1) Background: The estrogen decline during perimenopause can induce various disorders, including cognitive impairment. Phytoestrogens, such as isoflavones, lignans, and coumestans, have been tried as a popular alternative to avoid the side effects of conventional hormone replacement therapy, but their exact mechanisms and risk are not fully elucidated. In this study, we investigated the effects of isoflavone-enriched soybean leaves (IESLs) on the cognitive impairment induced by ovariectomy in female mice. (2) Methods: Ovariectomy was performed at 9 weeks of age to mimic menopausal women, and the behavior tests for cognition were conducted 15 weeks after the first administration. IESLs were administered for 18 weeks. (3) Results: The present study showed the effects of IESLs on the cognitive function in the OVX (ovariectomized) mice. Ovariectomy markedly increased the body weight and fat accumulation in the liver and perirenal fat, but IESL treatment significantly inhibited them. In the behavioral tests, ovariectomy impaired cognitive functions, but administration of IESLs restored it. In addition, in the OVX mice, administration of IESLs restored decreased estrogen receptor (ER) β and PI3K/Akt expression in the hippocampus. (4) Conclusions: The positive effects of IESLs on cognitive functions may be closely related to the ER-mediated PI3/Akt signaling pathway in the hippocampus.https://www.mdpi.com/2072-6643/14/22/4753menopausephytoestrogenisoflavonecognitionovariectomy |
| spellingShingle | Dae Young Yoo Soonwoong Jung Jae Soon Kang Ji Hyeong Baek Ki Hun Park Dong Hoon Lee Sang Soo Kang Hyun Joon Kim Isoflavone-Enriched Soybean Leaves (Glycine Max) Alleviate Cognitive Impairment Induced by Ovariectomy and Modulate PI3K/Akt Signaling in the Hippocampus of C57BL6 Mice Nutrients menopause phytoestrogen isoflavone cognition ovariectomy |
| title | Isoflavone-Enriched Soybean Leaves (Glycine Max) Alleviate Cognitive Impairment Induced by Ovariectomy and Modulate PI3K/Akt Signaling in the Hippocampus of C57BL6 Mice |
| title_full | Isoflavone-Enriched Soybean Leaves (Glycine Max) Alleviate Cognitive Impairment Induced by Ovariectomy and Modulate PI3K/Akt Signaling in the Hippocampus of C57BL6 Mice |
| title_fullStr | Isoflavone-Enriched Soybean Leaves (Glycine Max) Alleviate Cognitive Impairment Induced by Ovariectomy and Modulate PI3K/Akt Signaling in the Hippocampus of C57BL6 Mice |
| title_full_unstemmed | Isoflavone-Enriched Soybean Leaves (Glycine Max) Alleviate Cognitive Impairment Induced by Ovariectomy and Modulate PI3K/Akt Signaling in the Hippocampus of C57BL6 Mice |
| title_short | Isoflavone-Enriched Soybean Leaves (Glycine Max) Alleviate Cognitive Impairment Induced by Ovariectomy and Modulate PI3K/Akt Signaling in the Hippocampus of C57BL6 Mice |
| title_sort | isoflavone enriched soybean leaves glycine max alleviate cognitive impairment induced by ovariectomy and modulate pi3k akt signaling in the hippocampus of c57bl6 mice |
| topic | menopause phytoestrogen isoflavone cognition ovariectomy |
| url | https://www.mdpi.com/2072-6643/14/22/4753 |
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