Metabolic Disorders in Delirious Syndrome in Patients with Acute Poisoning with Gamma-Hydroxybutyric Acid and its Precursor
Abstract In 21 male patients aged 20 to 40 years, metabolic disorders in post-toxic delirious syndrome caused by gamma-hydroxybutyric acid poisoning and its precursors were studied. In the examined group of patients, hyperammonemia was detected in 71.4% of cases, metabolic lactic acidosis was reveal...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2020-10-01
|
| Series: | Неотложная медицинская помощь |
| Subjects: | |
| Online Access: | https://www.jnmp.ru/jour/article/view/933 |
| _version_ | 1797758133819408384 |
|---|---|
| author | A. G. Sinenchenko A. N. Lodyagin B. V. Batotsyrenov |
| author_facet | A. G. Sinenchenko A. N. Lodyagin B. V. Batotsyrenov |
| author_sort | A. G. Sinenchenko |
| collection | DOAJ |
| description | Abstract In 21 male patients aged 20 to 40 years, metabolic disorders in post-toxic delirious syndrome caused by gamma-hydroxybutyric acid poisoning and its precursors were studied. In the examined group of patients, hyperammonemia was detected in 71.4% of cases, metabolic lactic acidosis was revealed in 76.2%. The direct correlation between the severity of metabolic disorders and delirious syndrome according to DRS-R-98 scale was established. The statistically significant increase in capillary blood levels of lactate on day 3 of psychotic period was 4.9 mlmol/L and ammonia on day 5 was 187.0 mmol/L. The greatest severity of metabolic disorders was found in patients over the age of 27 years who systematically use the studied substances with narcotic effects for 7 months or more and combine their intake with other psychoactive substances. |
| first_indexed | 2024-03-12T18:25:38Z |
| format | Article |
| id | doaj.art-fae0b72b041f452fba575dcab3248a61 |
| institution | Directory Open Access Journal |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| last_indexed | 2024-03-12T18:25:38Z |
| publishDate | 2020-10-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj.art-fae0b72b041f452fba575dcab3248a612023-08-02T08:34:45ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172020-10-019221021410.23934/2223-9022-2020-9-2-210-214600Metabolic Disorders in Delirious Syndrome in Patients with Acute Poisoning with Gamma-Hydroxybutyric Acid and its PrecursorA. G. Sinenchenko0A. N. Lodyagin1B. V. Batotsyrenov2Narcology and Psycho-rehabilitation I.I. Dzhanelidze St. Petersburg Research Institute of Emergency MedicineNarcology and Psycho-rehabilitation I.I. Dzhanelidze St. Petersburg Research Institute of Emergency MedicineNarcology and Psycho-rehabilitation I.I. Dzhanelidze St. Petersburg Research Institute of Emergency MedicineAbstract In 21 male patients aged 20 to 40 years, metabolic disorders in post-toxic delirious syndrome caused by gamma-hydroxybutyric acid poisoning and its precursors were studied. In the examined group of patients, hyperammonemia was detected in 71.4% of cases, metabolic lactic acidosis was revealed in 76.2%. The direct correlation between the severity of metabolic disorders and delirious syndrome according to DRS-R-98 scale was established. The statistically significant increase in capillary blood levels of lactate on day 3 of psychotic period was 4.9 mlmol/L and ammonia on day 5 was 187.0 mmol/L. The greatest severity of metabolic disorders was found in patients over the age of 27 years who systematically use the studied substances with narcotic effects for 7 months or more and combine their intake with other psychoactive substances.https://www.jnmp.ru/jour/article/view/933metabolic disordersacute poisoninggamma-hydroxybutyric acidgamma-butyrolactonehyperammonemiametabolic lactic acidosis |
| spellingShingle | A. G. Sinenchenko A. N. Lodyagin B. V. Batotsyrenov Metabolic Disorders in Delirious Syndrome in Patients with Acute Poisoning with Gamma-Hydroxybutyric Acid and its Precursor Неотложная медицинская помощь metabolic disorders acute poisoning gamma-hydroxybutyric acid gamma-butyrolactone hyperammonemia metabolic lactic acidosis |
| title | Metabolic Disorders in Delirious Syndrome in Patients with Acute Poisoning with Gamma-Hydroxybutyric Acid and its Precursor |
| title_full | Metabolic Disorders in Delirious Syndrome in Patients with Acute Poisoning with Gamma-Hydroxybutyric Acid and its Precursor |
| title_fullStr | Metabolic Disorders in Delirious Syndrome in Patients with Acute Poisoning with Gamma-Hydroxybutyric Acid and its Precursor |
| title_full_unstemmed | Metabolic Disorders in Delirious Syndrome in Patients with Acute Poisoning with Gamma-Hydroxybutyric Acid and its Precursor |
| title_short | Metabolic Disorders in Delirious Syndrome in Patients with Acute Poisoning with Gamma-Hydroxybutyric Acid and its Precursor |
| title_sort | metabolic disorders in delirious syndrome in patients with acute poisoning with gamma hydroxybutyric acid and its precursor |
| topic | metabolic disorders acute poisoning gamma-hydroxybutyric acid gamma-butyrolactone hyperammonemia metabolic lactic acidosis |
| url | https://www.jnmp.ru/jour/article/view/933 |
| work_keys_str_mv | AT agsinenchenko metabolicdisordersindelirioussyndromeinpatientswithacutepoisoningwithgammahydroxybutyricacidanditsprecursor AT anlodyagin metabolicdisordersindelirioussyndromeinpatientswithacutepoisoningwithgammahydroxybutyricacidanditsprecursor AT bvbatotsyrenov metabolicdisordersindelirioussyndromeinpatientswithacutepoisoningwithgammahydroxybutyricacidanditsprecursor |