The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose
Laura J Hunter, David M Wood, Paul I DarganClinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust, London, UKAbstract: The nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, anti-inflammatory and antipyretic actions. They are common...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2011-07-01
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| Series: | Open Access Emergency Medicine |
| Online Access: | http://www.dovepress.com/the-patterns-of-toxicity-and-management-of-acute-nonsteroidal-anti-inf-a7818 |
| _version_ | 1819238144620363776 |
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| author | Hunter L Wood DM Dargan PI |
| author_facet | Hunter L Wood DM Dargan PI |
| author_sort | Hunter L |
| collection | DOAJ |
| description | Laura J Hunter, David M Wood, Paul I DarganClinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust, London, UKAbstract: The nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, anti-inflammatory and antipyretic actions. They are commonly taken in overdose in many areas of the world. The majority of patients with acute NSAID overdose will remain asymptomatic or develop minor self-limiting gastrointestinal symptoms. However, serious clinical sequelae have been reported in patients with acute NSAID overdose and these include convulsions, metabolic acidosis, coma and acute renal failure. There appear to be some differences between the NSAIDs in terms of the relative risk of these complications; in particular mefenamic acid is most commonly associated with convulsions. The management of these serious clinical features is largely supportive and there are no specific antidotes for acute NSAID toxicity.Keywords: nonsteroidal anti-inflammatory drugs (NSAID), ibuprofen, toxicity, poisoning, overdose, management |
| first_indexed | 2024-12-23T13:31:33Z |
| format | Article |
| id | doaj.art-fae3d2e6af504ccab2a67e1a5346c904 |
| institution | Directory Open Access Journal |
| issn | 1179-1500 |
| language | English |
| last_indexed | 2024-12-23T13:31:33Z |
| publishDate | 2011-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Open Access Emergency Medicine |
| spelling | doaj.art-fae3d2e6af504ccab2a67e1a5346c9042022-12-21T17:45:09ZengDove Medical PressOpen Access Emergency Medicine1179-15002011-07-012011default3948The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdoseHunter LWood DMDargan PILaura J Hunter, David M Wood, Paul I DarganClinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust, London, UKAbstract: The nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, anti-inflammatory and antipyretic actions. They are commonly taken in overdose in many areas of the world. The majority of patients with acute NSAID overdose will remain asymptomatic or develop minor self-limiting gastrointestinal symptoms. However, serious clinical sequelae have been reported in patients with acute NSAID overdose and these include convulsions, metabolic acidosis, coma and acute renal failure. There appear to be some differences between the NSAIDs in terms of the relative risk of these complications; in particular mefenamic acid is most commonly associated with convulsions. The management of these serious clinical features is largely supportive and there are no specific antidotes for acute NSAID toxicity.Keywords: nonsteroidal anti-inflammatory drugs (NSAID), ibuprofen, toxicity, poisoning, overdose, managementhttp://www.dovepress.com/the-patterns-of-toxicity-and-management-of-acute-nonsteroidal-anti-inf-a7818 |
| spellingShingle | Hunter L Wood DM Dargan PI The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose Open Access Emergency Medicine |
| title | The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose |
| title_full | The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose |
| title_fullStr | The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose |
| title_full_unstemmed | The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose |
| title_short | The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose |
| title_sort | patterns of toxicity and management of acute nonsteroidal anti inflammatory drug nsaid overdose |
| url | http://www.dovepress.com/the-patterns-of-toxicity-and-management-of-acute-nonsteroidal-anti-inf-a7818 |
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