Fat-1 Transgenic Mice With Augmented n3-Polyunsaturated Fatty Acids Are Protected From Liver Injury Caused by Acute-On-Chronic Ethanol Administration

Fat-1 Transgenic Mice With Augmented n3-Polyunsaturated Fatty Acids Are Protected From Liver Injury Caused by Acute-On-Chronic Ethanol Administration

Alcohol-associated liver disease (ALD) is the leading cause of liver disease worldwide, and alcohol-associated hepatitis (AH), a severe form of ALD, is a major contributor to the mortality and morbidity due to ALD. Many factors modulate susceptibility to ALD development and progression, including nu...

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Bibliographic Details
Main Authors: Jeffrey Warner, Josiah Hardesty, Ying Song, Rui Sun, Zhongbin Deng, Raobo Xu, Xinmin Yin, Xiang Zhang, Craig McClain, Dennis Warner, Irina Kirpich
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
alcohol-associated liver disease (ALD)
fat-1
n3 polyunsaturated fatty acids (n-3PUFAs)
plasminogen activator inhibitor (PAI-1)
NIAAA model
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.711590/full

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