The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes
Background: Patients undergoing (chemo) radiotherapy for oropharyngeal squamous cell carcinoma (OPSCC) are at high risk of malnutrition during and after treatment. Malnutrition can lead to poor tolerance to treatment, treatment interruptions, poor quality of life (QOL) and potentially reduced surviv...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/2/514 |
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| author | Jane Harrowfield Elizabeth Isenring Nicole Kiss Erin Laing Ruby Lipson-Smith Ben Britton |
| author_facet | Jane Harrowfield Elizabeth Isenring Nicole Kiss Erin Laing Ruby Lipson-Smith Ben Britton |
| author_sort | Jane Harrowfield |
| collection | DOAJ |
| description | Background: Patients undergoing (chemo) radiotherapy for oropharyngeal squamous cell carcinoma (OPSCC) are at high risk of malnutrition during and after treatment. Malnutrition can lead to poor tolerance to treatment, treatment interruptions, poor quality of life (QOL) and potentially reduced survival rate. Human papillomavirus (HPV) is now known as the major cause of OPSCC. However, research regarding its effect on nutritional outcomes is limited. The aim of this study was to examine the relationship between HPV status and nutritional outcomes, including malnutrition and weight loss during and after patients’ (chemo) radiotherapy treatment for OPSCC. <b>Methods:</b> This was a longitudinal cohort study comparing the nutritional outcomes of HPV-positive and negative OPSCC patients undergoing (chemo) radiotherapy. The primary outcome was nutritional status as measured using the Patient Generated-Subjective Global Assessment (PG-SGA). Secondary outcomes included loss of weight, depression, QOL and adverse events. <b>Results:</b> Although HPV-positive were less likely to be malnourished according to PG-SGA at the beginning of treatment, we found that the difference between malnutrition rates in response to treatment was not significantly different over the course of radiotherapy and 3 months post treatment. HPV-positive participants had significantly higher odds of experiencing >10% weight loss at three months post-treatment than HPV-negative participants (OR = 49.68, 95% CI (2.7, 912.86) <i>p</i> ≤ 0.01). <b>Conclusions:</b> The nutritional status of HPV positive and negative patients were both negatively affected by treatment and require similarly intense nutritional intervention. In acute recovery, HPV positive patients may require more intense intervention. At 3- months post treatment, both groups still showed nutritional symptoms that require nutritional intervention so ongoing nutritional support is essential. |
| first_indexed | 2024-03-09T05:39:41Z |
| format | Article |
| id | doaj.art-fae61728036c48a9bc70362742b1ec47 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T05:39:41Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-fae61728036c48a9bc70362742b1ec472023-12-03T12:26:11ZengMDPI AGNutrients2072-66432021-02-0113251410.3390/nu13020514The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional OutcomesJane Harrowfield0Elizabeth Isenring1Nicole Kiss2Erin Laing3Ruby Lipson-Smith4Ben Britton5Nutrition and Speech Pathology Department, Peter MacCallum Cancer Centre, Melbourne, 3000, AustraliaFaculty of Health Sciences and Medicine, Bond University, Gold Coast 4226, AustraliaInstitute for Physical Activity and Nutrition, Deakin University, Geelong 3220, AustraliaNutrition and Speech Pathology Department, Peter MacCallum Cancer Centre, Melbourne, 3000, AustraliaDepartment of Health Services Research, Peter MacCallum Cancer Centre, Melbourne 3000, AustraliaHunter New England Health, Newcastle 2305, AustraliaBackground: Patients undergoing (chemo) radiotherapy for oropharyngeal squamous cell carcinoma (OPSCC) are at high risk of malnutrition during and after treatment. Malnutrition can lead to poor tolerance to treatment, treatment interruptions, poor quality of life (QOL) and potentially reduced survival rate. Human papillomavirus (HPV) is now known as the major cause of OPSCC. However, research regarding its effect on nutritional outcomes is limited. The aim of this study was to examine the relationship between HPV status and nutritional outcomes, including malnutrition and weight loss during and after patients’ (chemo) radiotherapy treatment for OPSCC. <b>Methods:</b> This was a longitudinal cohort study comparing the nutritional outcomes of HPV-positive and negative OPSCC patients undergoing (chemo) radiotherapy. The primary outcome was nutritional status as measured using the Patient Generated-Subjective Global Assessment (PG-SGA). Secondary outcomes included loss of weight, depression, QOL and adverse events. <b>Results:</b> Although HPV-positive were less likely to be malnourished according to PG-SGA at the beginning of treatment, we found that the difference between malnutrition rates in response to treatment was not significantly different over the course of radiotherapy and 3 months post treatment. HPV-positive participants had significantly higher odds of experiencing >10% weight loss at three months post-treatment than HPV-negative participants (OR = 49.68, 95% CI (2.7, 912.86) <i>p</i> ≤ 0.01). <b>Conclusions:</b> The nutritional status of HPV positive and negative patients were both negatively affected by treatment and require similarly intense nutritional intervention. In acute recovery, HPV positive patients may require more intense intervention. At 3- months post treatment, both groups still showed nutritional symptoms that require nutritional intervention so ongoing nutritional support is essential.https://www.mdpi.com/2072-6643/13/2/514oropharyngeal cancerOPSCChead and neckhuman papillomavirusHPVmalnutrition |
| spellingShingle | Jane Harrowfield Elizabeth Isenring Nicole Kiss Erin Laing Ruby Lipson-Smith Ben Britton The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes Nutrients oropharyngeal cancer OPSCC head and neck human papillomavirus HPV malnutrition |
| title | The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
| title_full | The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
| title_fullStr | The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
| title_full_unstemmed | The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
| title_short | The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
| title_sort | impact of human papillomavirus hpv associated oropharyngeal squamous cell carcinoma opscc on nutritional outcomes |
| topic | oropharyngeal cancer OPSCC head and neck human papillomavirus HPV malnutrition |
| url | https://www.mdpi.com/2072-6643/13/2/514 |
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