The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum
A combination of sulphamethoxazol SMX and trimethoprim TMP is widly used in the treatment of various systemic infections . This investigation was carried out to see the effect of increasing concentration of surface active agents ( SAA ) used in suspensions on the absorption of both drugs from isola...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Pharmacy / Mustansiriyah University
2008-06-01
|
| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/372 |
| _version_ | 1827293769319317504 |
|---|---|
| author | Manal khalid abdul ridha |
| author_facet | Manal khalid abdul ridha |
| author_sort | Manal khalid abdul ridha |
| collection | DOAJ |
| description |
A combination of sulphamethoxazol SMX and trimethoprim TMP is widly used in the treatment of various systemic infections . This investigation was carried out to see the effect of increasing concentration of surface active agents ( SAA ) used in suspensions on the absorption of both drugs from isolated rabbit ileum . The study was carried out at PH 7.4 and at 37°C . The SAA chosen were tween 80, sodium laurylsulphate ( SLS ), polyethylene glycole ( PEG400 ), and PEG4000 at a concentrations of 0.1%w/v , 1%w/v, 2%w/v and 15% w/v (Note : 15% was chosen for the purpose of the investigation not as a concentration for formulation ). It was found that the absorption of both drugs decreased as a function of increasing the concentration of the different SAA.
|
| first_indexed | 2024-04-24T13:44:32Z |
| format | Article |
| id | doaj.art-fae8f94a7add4bebabf9006bd63de997 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:44:32Z |
| publishDate | 2008-06-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-fae8f94a7add4bebabf9006bd63de9972024-04-04T06:59:18ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2008-06-015110.32947/ajps.v5i1.372The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileumManal khalid abdul ridha0Department of pharmacotheraputics, Collage of pharmacy, Al – Mustansiriya University A combination of sulphamethoxazol SMX and trimethoprim TMP is widly used in the treatment of various systemic infections . This investigation was carried out to see the effect of increasing concentration of surface active agents ( SAA ) used in suspensions on the absorption of both drugs from isolated rabbit ileum . The study was carried out at PH 7.4 and at 37°C . The SAA chosen were tween 80, sodium laurylsulphate ( SLS ), polyethylene glycole ( PEG400 ), and PEG4000 at a concentrations of 0.1%w/v , 1%w/v, 2%w/v and 15% w/v (Note : 15% was chosen for the purpose of the investigation not as a concentration for formulation ). It was found that the absorption of both drugs decreased as a function of increasing the concentration of the different SAA. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/372 |
| spellingShingle | Manal khalid abdul ridha The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| title | The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum |
| title_full | The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum |
| title_fullStr | The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum |
| title_full_unstemmed | The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum |
| title_short | The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum |
| title_sort | effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/372 |
| work_keys_str_mv | AT manalkhalidabdulridha theeffectofdifferentconcentrationsofsurfaceactiveagentontheabsorptionofsulphamethoxazoleandtrimethoprimfromrabbitileum AT manalkhalidabdulridha effectofdifferentconcentrationsofsurfaceactiveagentontheabsorptionofsulphamethoxazoleandtrimethoprimfromrabbitileum |