Hemolysin Co-Regulatory Protein 1 Enhances the Virulence of Clinically Isolated <i>Escherichia coli</i> in KM Mice by Increasing Inflammation and Inducing Pyroptosis

Hemolysin Co-Regulatory Protein 1 Enhances the Virulence of Clinically Isolated <i>Escherichia coli</i> in KM Mice by Increasing Inflammation and Inducing Pyroptosis

Hemolysin-coregulated protein 1 (Hcp1) is an effector released by the type VI secretion system (T6SS) in certain pathogenic strains of <i>Escherichia coli</i> (<i>E. coli</i>) that causes apoptosis and contributes to the development of meningitis. The exact toxic consequences...

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Bibliographic Details
Main Authors: Hao Wang, Long-Bao Lv, Li-Ping Chen, Jin-Long Xiao, Jue Shen, Bin Gao, Jin-Gang Zhao, Dong-Mei Han, Bin-Xun Chen, Shuai Wang, Gen Liu, Ai-Guo Xin, Peng Xiao, Hong Gao
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Toxins
Subjects:
<i>E. coli</i>
Hcp1
pathogenicity
pyroptosis
inflammation
AKI
Online Access:https://www.mdpi.com/2072-6651/15/3/171

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