LncRNA HOTAIR: A Potential Prognostic Factor and Therapeutic Target in Human Cancers
Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of gene expression and physiological processes. LncRNAs are a class of ncRNAs of 200 nucleotides in length. HOX transcript antisense RNA (HOTAIR), a trans-acting lncRNA with regulatory function on transcription, can repress gene expre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.679244/full |
| _version_ | 1818668810645798912 |
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| author | Xiaoru Xin Qianan Li Jinyong Fang Tiejun Zhao |
| author_facet | Xiaoru Xin Qianan Li Jinyong Fang Tiejun Zhao |
| author_sort | Xiaoru Xin |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of gene expression and physiological processes. LncRNAs are a class of ncRNAs of 200 nucleotides in length. HOX transcript antisense RNA (HOTAIR), a trans-acting lncRNA with regulatory function on transcription, can repress gene expression by recruiting chromatin modifiers. HOTAIR is an oncogenic lncRNA, and numerous studies have determined that HOTAIR is highly upregulated in a wide variety of human cancers. In this review, we briefly summarize the impact of lncRNA HOTAIR expression and functions on different human solid tumors, and emphasize the potential of HOTAIR on tumor prognosis and therapy. Here, we review the recent studies that highlight the prognostic potential of HOTAIR in drug resistance and survival, and the progress of therapies developed to target HOTAIR to date. Furthermore, targeting HOTAIR results in the suppression of HOTAIR expression or function. Thus, HOTAIR knockdown exhibits great therapeutic potential in various cancers, indicating that targeting lncRNA HOTAIR may serve as a promising strategy for cancer therapy. We also propose that preclinical studies involving HOTAIR are required to provide a better understanding of the exact molecular mechanisms underlying the dysregulation of its expression and function in different human cancers and to explore effective methods of targeting HOTAIR and engineering efficient and targeted drug delivery methods in vivo. |
| first_indexed | 2024-12-17T06:42:14Z |
| format | Article |
| id | doaj.art-faeaaf6064f84ef09d5b197b05d3162b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T06:42:14Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-faeaaf6064f84ef09d5b197b05d3162b2022-12-21T21:59:50ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-07-011110.3389/fonc.2021.679244679244LncRNA HOTAIR: A Potential Prognostic Factor and Therapeutic Target in Human CancersXiaoru Xin0Qianan Li1Jinyong Fang2Tiejun Zhao3College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, ChinaCollege of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, ChinaDepartment of Science and Education, Jinhua Guangfu Oncology Hospital, Jinhua, ChinaCollege of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, ChinaLong non-coding RNAs (lncRNAs) are emerging as crucial regulators of gene expression and physiological processes. LncRNAs are a class of ncRNAs of 200 nucleotides in length. HOX transcript antisense RNA (HOTAIR), a trans-acting lncRNA with regulatory function on transcription, can repress gene expression by recruiting chromatin modifiers. HOTAIR is an oncogenic lncRNA, and numerous studies have determined that HOTAIR is highly upregulated in a wide variety of human cancers. In this review, we briefly summarize the impact of lncRNA HOTAIR expression and functions on different human solid tumors, and emphasize the potential of HOTAIR on tumor prognosis and therapy. Here, we review the recent studies that highlight the prognostic potential of HOTAIR in drug resistance and survival, and the progress of therapies developed to target HOTAIR to date. Furthermore, targeting HOTAIR results in the suppression of HOTAIR expression or function. Thus, HOTAIR knockdown exhibits great therapeutic potential in various cancers, indicating that targeting lncRNA HOTAIR may serve as a promising strategy for cancer therapy. We also propose that preclinical studies involving HOTAIR are required to provide a better understanding of the exact molecular mechanisms underlying the dysregulation of its expression and function in different human cancers and to explore effective methods of targeting HOTAIR and engineering efficient and targeted drug delivery methods in vivo.https://www.frontiersin.org/articles/10.3389/fonc.2021.679244/fullHOTAIRcancerprognosistherapypotentialdrug resistance |
| spellingShingle | Xiaoru Xin Qianan Li Jinyong Fang Tiejun Zhao LncRNA HOTAIR: A Potential Prognostic Factor and Therapeutic Target in Human Cancers Frontiers in Oncology HOTAIR cancer prognosis therapy potential drug resistance |
| title | LncRNA HOTAIR: A Potential Prognostic Factor and Therapeutic Target in Human Cancers |
| title_full | LncRNA HOTAIR: A Potential Prognostic Factor and Therapeutic Target in Human Cancers |
| title_fullStr | LncRNA HOTAIR: A Potential Prognostic Factor and Therapeutic Target in Human Cancers |
| title_full_unstemmed | LncRNA HOTAIR: A Potential Prognostic Factor and Therapeutic Target in Human Cancers |
| title_short | LncRNA HOTAIR: A Potential Prognostic Factor and Therapeutic Target in Human Cancers |
| title_sort | lncrna hotair a potential prognostic factor and therapeutic target in human cancers |
| topic | HOTAIR cancer prognosis therapy potential drug resistance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.679244/full |
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