Role of intraperitoneal chemotherapy in gastric cancer
Peritoneal carcinomatosis (PC) is the most frequent mode of recurrence and metastasis in gastric cancer (GC). Apart from being potentially lethal, PC poses multiple complexities hindering cancer directed treatment, such as bowel obstruction, bowel perforation with bowel fistulae, nutritional depriva...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Surgery in Practice and Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666262020300231 |
| _version_ | 1818676255535398912 |
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| author | Amir Parray Vikas Gupta Vikram A. Chaudhari Shailesh V. Shrikhande Manish S. Bhandare |
| author_facet | Amir Parray Vikas Gupta Vikram A. Chaudhari Shailesh V. Shrikhande Manish S. Bhandare |
| author_sort | Amir Parray |
| collection | DOAJ |
| description | Peritoneal carcinomatosis (PC) is the most frequent mode of recurrence and metastasis in gastric cancer (GC). Apart from being potentially lethal, PC poses multiple complexities hindering cancer directed treatment, such as bowel obstruction, bowel perforation with bowel fistulae, nutritional deprivation and intractable malignant ascites; all of which finally culminate into agonizing death with immeasurable suffering. Recognition of PC as locoregional rather than a systemic disease has opened a treatment gateway where cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) are now increasingly utilized in the treatment pathways. In this review, we take a contemporary view on the management of gastric cancer at risk of PC or gastric cancer presenting with PC. We highlight the rationale of intraperitoneal chemotherapy and drugs used, followed by different scenarios and different modalities of intraperitoneal chemotherapy in light of the available literature. |
| first_indexed | 2024-12-17T08:40:34Z |
| format | Article |
| id | doaj.art-faebc3e16cac48be8e37a53ee2b87f79 |
| institution | Directory Open Access Journal |
| issn | 2666-2620 |
| language | English |
| last_indexed | 2024-12-17T08:40:34Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Surgery in Practice and Science |
| spelling | doaj.art-faebc3e16cac48be8e37a53ee2b87f792022-12-21T21:56:21ZengElsevierSurgery in Practice and Science2666-26202021-03-014100025Role of intraperitoneal chemotherapy in gastric cancerAmir Parray0Vikas Gupta1Vikram A. Chaudhari2Shailesh V. Shrikhande3Manish S. Bhandare4Gastrointestinal and Hepato-Pancreato-Biliary Service, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, 400012, Maharashtra, IndiaGastrointestinal and Hepato-Pancreato-Biliary Service, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, 400012, Maharashtra, IndiaGastrointestinal and Hepato-Pancreato-Biliary Service, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, 400012, Maharashtra, IndiaGastrointestinal and Hepato-Pancreato-Biliary Service, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, 400012, Maharashtra, IndiaCorresponding author.; Gastrointestinal and Hepato-Pancreato-Biliary Service, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, 400012, Maharashtra, IndiaPeritoneal carcinomatosis (PC) is the most frequent mode of recurrence and metastasis in gastric cancer (GC). Apart from being potentially lethal, PC poses multiple complexities hindering cancer directed treatment, such as bowel obstruction, bowel perforation with bowel fistulae, nutritional deprivation and intractable malignant ascites; all of which finally culminate into agonizing death with immeasurable suffering. Recognition of PC as locoregional rather than a systemic disease has opened a treatment gateway where cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) are now increasingly utilized in the treatment pathways. In this review, we take a contemporary view on the management of gastric cancer at risk of PC or gastric cancer presenting with PC. We highlight the rationale of intraperitoneal chemotherapy and drugs used, followed by different scenarios and different modalities of intraperitoneal chemotherapy in light of the available literature.http://www.sciencedirect.com/science/article/pii/S2666262020300231Gastric cancerIntraperitoneal chemotherapyHIPECPIPAC |
| spellingShingle | Amir Parray Vikas Gupta Vikram A. Chaudhari Shailesh V. Shrikhande Manish S. Bhandare Role of intraperitoneal chemotherapy in gastric cancer Surgery in Practice and Science Gastric cancer Intraperitoneal chemotherapy HIPEC PIPAC |
| title | Role of intraperitoneal chemotherapy in gastric cancer |
| title_full | Role of intraperitoneal chemotherapy in gastric cancer |
| title_fullStr | Role of intraperitoneal chemotherapy in gastric cancer |
| title_full_unstemmed | Role of intraperitoneal chemotherapy in gastric cancer |
| title_short | Role of intraperitoneal chemotherapy in gastric cancer |
| title_sort | role of intraperitoneal chemotherapy in gastric cancer |
| topic | Gastric cancer Intraperitoneal chemotherapy HIPEC PIPAC |
| url | http://www.sciencedirect.com/science/article/pii/S2666262020300231 |
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