Clotting state after cardioversion of atrial fibrillation: <it>a haemostasis index could detect the relationship with the arrhythmia duration</it>
<p>Abstract</p> <p>Background</p> <p>Fibrin D-dimer levels have been advocated as an useful clinical marker of thrombogenesis.</p> <p>Hypothesis</p> <p>We hypothesized that i) there is a hyperclotting state after the return of atrial fibrillation...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2005-03-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | http://www.thrombosisjournal.com/content/3/1/2 |
| _version_ | 1818113462423781376 |
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| author | Chalikias Georgios Hotidis Athanasios Stakos Dimitrios Tziakas Dimitrios Kartasis Zafirios Hatzinikolaou-Kotsakou Eleni Bourikas Georgios Hatseras Dimitrios I |
| author_facet | Chalikias Georgios Hotidis Athanasios Stakos Dimitrios Tziakas Dimitrios Kartasis Zafirios Hatzinikolaou-Kotsakou Eleni Bourikas Georgios Hatseras Dimitrios I |
| author_sort | Chalikias Georgios |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Fibrin D-dimer levels have been advocated as an useful clinical marker of thrombogenesis.</p> <p>Hypothesis</p> <p>We hypothesized that i) there is a hyperclotting state after the return of atrial fibrillation to sinus rhythm, ii) the measurement of plasma D-Dimer levels might be a good screening tool of this clotting status, and iii) the duration of arrhythmia influences the haemostasis measured by plasma D-Dimer levels.</p> <p>Methods</p> <p>Forty-two patients with atrial fibrillation undergoing cardioversion were divided into two groups: in Group A (n = 24,14 male, 56 ± 11 years) the duration of atrial fibrillation was 72 hours or more (142.7 ± 103.8 hours), in Group B (n = 18, 10 male, 61 ± 13 years) the duration of atrial fibrillation was less than 72 hours (25 ± 16 hours). Plasma fibrin D-dimer levels were measured by enzyme immunoassay before, and 36 hours after, cardioversion. The change of plasma D-dimer levels 36 hours after cardioversion was calculated as delta-D-dimer.</p> <p>Results</p> <p>There were no significant differences in demographic, clinical, and echocardiographic data, and the success of cardioversion between the two groups. Compared to the control, the baseline D-dimer levels were significantly higher in both groups. The delta D-dimer levels were significantly higher in Group A than in Group B (p < 0.005). Furthermore, plasma D-dimer levels 36 hours after cardioversion (r = 0.52, p = 0.0016) and delta-D-dimer levels (r = 0.73, p < 0.0001) showed significant correlations with the duration of atrial fibrillation.</p> <p>Conclusion</p> <p>The longer duration of the atrial fibrillation episode could lead to a more prominent cardiovascular hyperclotting state after cardioversion, and the mean changes of plasma D-Dimer levels could be used as an useful clinical marker of the clotting state after atrial systole return.</p> |
| first_indexed | 2024-12-11T03:35:13Z |
| format | Article |
| id | doaj.art-faec113213b94899842bb5795812ff33 |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-12-11T03:35:13Z |
| publishDate | 2005-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-faec113213b94899842bb5795812ff332022-12-22T01:22:17ZengBMCThrombosis Journal1477-95602005-03-0131210.1186/1477-9560-3-2Clotting state after cardioversion of atrial fibrillation: <it>a haemostasis index could detect the relationship with the arrhythmia duration</it>Chalikias GeorgiosHotidis AthanasiosStakos DimitriosTziakas DimitriosKartasis ZafiriosHatzinikolaou-Kotsakou EleniBourikas GeorgiosHatseras Dimitrios I<p>Abstract</p> <p>Background</p> <p>Fibrin D-dimer levels have been advocated as an useful clinical marker of thrombogenesis.</p> <p>Hypothesis</p> <p>We hypothesized that i) there is a hyperclotting state after the return of atrial fibrillation to sinus rhythm, ii) the measurement of plasma D-Dimer levels might be a good screening tool of this clotting status, and iii) the duration of arrhythmia influences the haemostasis measured by plasma D-Dimer levels.</p> <p>Methods</p> <p>Forty-two patients with atrial fibrillation undergoing cardioversion were divided into two groups: in Group A (n = 24,14 male, 56 ± 11 years) the duration of atrial fibrillation was 72 hours or more (142.7 ± 103.8 hours), in Group B (n = 18, 10 male, 61 ± 13 years) the duration of atrial fibrillation was less than 72 hours (25 ± 16 hours). Plasma fibrin D-dimer levels were measured by enzyme immunoassay before, and 36 hours after, cardioversion. The change of plasma D-dimer levels 36 hours after cardioversion was calculated as delta-D-dimer.</p> <p>Results</p> <p>There were no significant differences in demographic, clinical, and echocardiographic data, and the success of cardioversion between the two groups. Compared to the control, the baseline D-dimer levels were significantly higher in both groups. The delta D-dimer levels were significantly higher in Group A than in Group B (p < 0.005). Furthermore, plasma D-dimer levels 36 hours after cardioversion (r = 0.52, p = 0.0016) and delta-D-dimer levels (r = 0.73, p < 0.0001) showed significant correlations with the duration of atrial fibrillation.</p> <p>Conclusion</p> <p>The longer duration of the atrial fibrillation episode could lead to a more prominent cardiovascular hyperclotting state after cardioversion, and the mean changes of plasma D-Dimer levels could be used as an useful clinical marker of the clotting state after atrial systole return.</p>http://www.thrombosisjournal.com/content/3/1/2Atrial fibrillationhaemostatic markers |
| spellingShingle | Chalikias Georgios Hotidis Athanasios Stakos Dimitrios Tziakas Dimitrios Kartasis Zafirios Hatzinikolaou-Kotsakou Eleni Bourikas Georgios Hatseras Dimitrios I Clotting state after cardioversion of atrial fibrillation: <it>a haemostasis index could detect the relationship with the arrhythmia duration</it> Thrombosis Journal Atrial fibrillation haemostatic markers |
| title | Clotting state after cardioversion of atrial fibrillation: <it>a haemostasis index could detect the relationship with the arrhythmia duration</it> |
| title_full | Clotting state after cardioversion of atrial fibrillation: <it>a haemostasis index could detect the relationship with the arrhythmia duration</it> |
| title_fullStr | Clotting state after cardioversion of atrial fibrillation: <it>a haemostasis index could detect the relationship with the arrhythmia duration</it> |
| title_full_unstemmed | Clotting state after cardioversion of atrial fibrillation: <it>a haemostasis index could detect the relationship with the arrhythmia duration</it> |
| title_short | Clotting state after cardioversion of atrial fibrillation: <it>a haemostasis index could detect the relationship with the arrhythmia duration</it> |
| title_sort | clotting state after cardioversion of atrial fibrillation it a haemostasis index could detect the relationship with the arrhythmia duration it |
| topic | Atrial fibrillation haemostatic markers |
| url | http://www.thrombosisjournal.com/content/3/1/2 |
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