A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice.
In the past decades ancient DNA research has brought numerous insights to archaeological research where traditional approaches were limited. The determination of sex in human skeletal remains is often challenging for physical anthropologists when dealing with incomplete, juvenile or pathological spe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5051676?pdf=render |
| _version_ | 1819204009731293184 |
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| author | Alissa Mittnik Chuan-Chao Wang Jiří Svoboda Johannes Krause |
| author_facet | Alissa Mittnik Chuan-Chao Wang Jiří Svoboda Johannes Krause |
| author_sort | Alissa Mittnik |
| collection | DOAJ |
| description | In the past decades ancient DNA research has brought numerous insights to archaeological research where traditional approaches were limited. The determination of sex in human skeletal remains is often challenging for physical anthropologists when dealing with incomplete, juvenile or pathological specimens. Molecular approaches allow sexing on the basis of sex-specific markers or by calculating the ratio of DNA derived from different chromosomes. Here we propose a novel approach that relies on the ratio of X chromosome-derived shotgun sequencing data to the autosomal coverage, thus establishing the probability of an XX or XY karyotype. Applying this approach to the individuals of the Upper Paleolithic triple burial of Dolní Věstonice reveals that all three skeletons, including the individual DV 15, whose sex has long been debated due to a pathological condition, were male. |
| first_indexed | 2024-12-23T04:29:00Z |
| format | Article |
| id | doaj.art-faec51944da64415b732c0c976acce26 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T04:29:00Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-faec51944da64415b732c0c976acce262022-12-21T18:00:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016301910.1371/journal.pone.0163019A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice.Alissa MittnikChuan-Chao WangJiří SvobodaJohannes KrauseIn the past decades ancient DNA research has brought numerous insights to archaeological research where traditional approaches were limited. The determination of sex in human skeletal remains is often challenging for physical anthropologists when dealing with incomplete, juvenile or pathological specimens. Molecular approaches allow sexing on the basis of sex-specific markers or by calculating the ratio of DNA derived from different chromosomes. Here we propose a novel approach that relies on the ratio of X chromosome-derived shotgun sequencing data to the autosomal coverage, thus establishing the probability of an XX or XY karyotype. Applying this approach to the individuals of the Upper Paleolithic triple burial of Dolní Věstonice reveals that all three skeletons, including the individual DV 15, whose sex has long been debated due to a pathological condition, were male.http://europepmc.org/articles/PMC5051676?pdf=render |
| spellingShingle | Alissa Mittnik Chuan-Chao Wang Jiří Svoboda Johannes Krause A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice. PLoS ONE |
| title | A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice. |
| title_full | A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice. |
| title_fullStr | A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice. |
| title_full_unstemmed | A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice. |
| title_short | A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice. |
| title_sort | molecular approach to the sexing of the triple burial at the upper paleolithic site of dolni vestonice |
| url | http://europepmc.org/articles/PMC5051676?pdf=render |
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