Blocking HIF to Enhance NK Cells: Hints for New Anti-Tumor Therapeutic Strategies?
Natural Killer (NK) cells are becoming an ever more promising tool to design new anti-tumor strategies. However, two major issues are still a challenge to obtain versatile and effective NK-based therapies: the way to maximize the persistency of powerful NK effectors in the patient, and the way to ov...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/9/10/1144 |
| _version_ | 1797513035150000128 |
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| author | Massimo Vitale Monica Parodi |
| author_facet | Massimo Vitale Monica Parodi |
| author_sort | Massimo Vitale |
| collection | DOAJ |
| description | Natural Killer (NK) cells are becoming an ever more promising tool to design new anti-tumor strategies. However, two major issues are still a challenge to obtain versatile and effective NK-based therapies: the way to maximize the persistency of powerful NK effectors in the patient, and the way to overcome the multiple escape mechanisms that keep away or suppress NK cells at the tumor site. In this regard, targeting the hypoxia-inducible factors (HIFs), which is important for both tumor progression and immune suppression, may be an opportunity. Especially, in the context of the ongoing studies focused on more effective NK-based therapeutic products. |
| first_indexed | 2024-03-10T06:10:00Z |
| format | Article |
| id | doaj.art-faef8f6c3cf64105a86e6e1f6b782724 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T06:10:00Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-faef8f6c3cf64105a86e6e1f6b7827242023-11-22T20:15:51ZengMDPI AGVaccines2076-393X2021-10-01910114410.3390/vaccines9101144Blocking HIF to Enhance NK Cells: Hints for New Anti-Tumor Therapeutic Strategies?Massimo Vitale0Monica Parodi1UO Immunologia, IRCCS Ospedale Policlinico San Martino Genova, 16132 Genoa, ItalyUO Immunologia, IRCCS Ospedale Policlinico San Martino Genova, 16132 Genoa, ItalyNatural Killer (NK) cells are becoming an ever more promising tool to design new anti-tumor strategies. However, two major issues are still a challenge to obtain versatile and effective NK-based therapies: the way to maximize the persistency of powerful NK effectors in the patient, and the way to overcome the multiple escape mechanisms that keep away or suppress NK cells at the tumor site. In this regard, targeting the hypoxia-inducible factors (HIFs), which is important for both tumor progression and immune suppression, may be an opportunity. Especially, in the context of the ongoing studies focused on more effective NK-based therapeutic products.https://www.mdpi.com/2076-393X/9/10/1144NK cellstumorsHIF |
| spellingShingle | Massimo Vitale Monica Parodi Blocking HIF to Enhance NK Cells: Hints for New Anti-Tumor Therapeutic Strategies? Vaccines NK cells tumors HIF |
| title | Blocking HIF to Enhance NK Cells: Hints for New Anti-Tumor Therapeutic Strategies? |
| title_full | Blocking HIF to Enhance NK Cells: Hints for New Anti-Tumor Therapeutic Strategies? |
| title_fullStr | Blocking HIF to Enhance NK Cells: Hints for New Anti-Tumor Therapeutic Strategies? |
| title_full_unstemmed | Blocking HIF to Enhance NK Cells: Hints for New Anti-Tumor Therapeutic Strategies? |
| title_short | Blocking HIF to Enhance NK Cells: Hints for New Anti-Tumor Therapeutic Strategies? |
| title_sort | blocking hif to enhance nk cells hints for new anti tumor therapeutic strategies |
| topic | NK cells tumors HIF |
| url | https://www.mdpi.com/2076-393X/9/10/1144 |
| work_keys_str_mv | AT massimovitale blockinghiftoenhancenkcellshintsfornewantitumortherapeuticstrategies AT monicaparodi blockinghiftoenhancenkcellshintsfornewantitumortherapeuticstrategies |