Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B
Clostridium difficile infections can induce mild to severe diarrhoea and the often associated characteristic pseudomembranous colitis. Two protein toxins, the large glucosyltransferases TcdA and TcdB, are the main pathogenicity factors that can induce all clinical symptoms in animal models. The clas...
Main Authors: | Claudia Frädrich, Lara-Antonia Beer, Ralf Gerhard |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-01-01
|
Series: | Toxins |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6651/8/1/25 |
Similar Items
-
Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects
by: Stefano Di Bella, et al.
Published: (2016-05-01) -
The Combined Repetitive Oligopeptides of Clostridium difficile Toxin A Counteract Premature Cleavage of the Glucosyl-Transferase Domain by Stabilizing Protein Conformation
by: Alexandra Olling, et al.
Published: (2014-07-01) -
EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin
by: Leonie Schnell, et al.
Published: (2016-04-01) -
The Enterotoxicity of Clostridium difficile Toxins
by: Hanping Feng, et al.
Published: (2010-07-01) -
Toxin-Specific Antibodies for the Treatment of Clostridium difficile: Current Status and Future Perspectives
by: Greg Hussack, et al.
Published: (2010-05-01)