A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing
Catecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein coupled receptors: D1-like and D2-like dopami...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/23/1/50 |
| _version_ | 1819147594498048000 |
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| author | Alexandra R. Vaughn Michael James Davis Raja K. Sivamani Roslyn Rivkah Isseroff |
| author_facet | Alexandra R. Vaughn Michael James Davis Raja K. Sivamani Roslyn Rivkah Isseroff |
| author_sort | Alexandra R. Vaughn |
| collection | DOAJ |
| description | Catecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein coupled receptors: D1-like and D2-like dopamine receptors. Dopamine may enhance angiogenesis and wound healing through its action on dopamine D1 receptors, while impairing wound healing when activating D2 receptors. This review summarizes the evidence for the role of dopamine in wound healing and describes potential mechanisms behind its action on D1 versus D2-like receptors in the skin. |
| first_indexed | 2024-12-22T13:32:18Z |
| format | Article |
| id | doaj.art-faf066eff7a3444590bbed06a82df2ee |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T13:32:18Z |
| publishDate | 2017-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-faf066eff7a3444590bbed06a82df2ee2022-12-21T18:24:09ZengMDPI AGMolecules1420-30492017-12-012315010.3390/molecules23010050molecules23010050A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound HealingAlexandra R. Vaughn0Michael James Davis1Raja K. Sivamani2Roslyn Rivkah Isseroff3Department of Dermatology, University of California–Davis, Sacramento, CA 95816, USAEmory University School of Medicine, Atlanta, GA 30307, USADepartment of Dermatology, University of California–Davis, Sacramento, CA 95816, USADepartment of Dermatology, University of California–Davis, Sacramento, CA 95816, USACatecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein coupled receptors: D1-like and D2-like dopamine receptors. Dopamine may enhance angiogenesis and wound healing through its action on dopamine D1 receptors, while impairing wound healing when activating D2 receptors. This review summarizes the evidence for the role of dopamine in wound healing and describes potential mechanisms behind its action on D1 versus D2-like receptors in the skin.https://www.mdpi.com/1420-3049/23/1/50woundsdopaminewound healing |
| spellingShingle | Alexandra R. Vaughn Michael James Davis Raja K. Sivamani Roslyn Rivkah Isseroff A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing Molecules wounds dopamine wound healing |
| title | A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing |
| title_full | A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing |
| title_fullStr | A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing |
| title_full_unstemmed | A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing |
| title_short | A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing |
| title_sort | concise review of the conflicting roles of dopamine 1 versus dopamine 2 receptors in wound healing |
| topic | wounds dopamine wound healing |
| url | https://www.mdpi.com/1420-3049/23/1/50 |
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