Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1

Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1

Background/Aims: Epithelial-to-mesenchymal transition (EMT) plays an essential role in the transition from early to invasive phenotype, however the underlying mechanisms still remain elusive. Herein, we propose a mechanism through which the class-III deacetylase SIRT1 regulates EMT in ovarian cancer...

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Bibliographic Details
Main Authors: Upasana Ray, Sib Sankar Roy, Shreya Roy Chowdhury
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
EMT
Lysophosphatidic acid
SIRT1
Ovarian cancer
Online Access:http://www.karger.com/Article/FullText/458744

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