The use of unripe pawpaw for wound bed preparation following radiation-induced sacral ulcer: A case report and review of literature
Radiation wounds are very difficult to manage due to poor vascular status, excessive matrix metalloproteinases, and abnormal myofibroblast function. Such wound beds do not adequately support conventional resurfacing as do nonradiate beds. We present a 46-year-old female with a sacral radiation ulcer...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Nigerian Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.njmonline.org/article.asp?issn=1115-2613;year=2021;volume=30;issue=3;spage=339;epage=341;aulast=Nwankwo |
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| author | Ezekiel Uchechukwu Nwankwo Charles Chidiebele Maduba Victor Ifeanyichukwu Modekwe Ugochukwu Uzodimma Nnadozie |
| author_facet | Ezekiel Uchechukwu Nwankwo Charles Chidiebele Maduba Victor Ifeanyichukwu Modekwe Ugochukwu Uzodimma Nnadozie |
| author_sort | Ezekiel Uchechukwu Nwankwo |
| collection | DOAJ |
| description | Radiation wounds are very difficult to manage due to poor vascular status, excessive matrix metalloproteinases, and abnormal myofibroblast function. Such wound beds do not adequately support conventional resurfacing as do nonradiate beds. We present a 46-year-old female with a sacral radiation ulcer, which had earlier failed to support flap cover on two instances after bed preparation with conventional honey dressing and negative pressure dressing, but was subsequently successfully managed with unripe pawpaw wound bed preparation. A re-elevation of the right gluteal myocutaneous flap proved successful and satisfactory. The finding may have resulted from both enzymatic properties of unripe pawpaw and its ability to break the biofilms and to locally supply the ascorbic acid necessary for collagen synthesis and granulation tissue formation. |
| first_indexed | 2024-12-22T14:55:33Z |
| format | Article |
| id | doaj.art-faf2980b6487410bbe7ae94d77e6492e |
| institution | Directory Open Access Journal |
| issn | 1115-2613 |
| language | English |
| last_indexed | 2024-12-22T14:55:33Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Nigerian Journal of Medicine |
| spelling | doaj.art-faf2980b6487410bbe7ae94d77e6492e2022-12-21T18:22:14ZengWolters Kluwer Medknow PublicationsNigerian Journal of Medicine1115-26132021-01-0130333934110.4103/NJM.NJM_209_20The use of unripe pawpaw for wound bed preparation following radiation-induced sacral ulcer: A case report and review of literatureEzekiel Uchechukwu NwankwoCharles Chidiebele MadubaVictor Ifeanyichukwu ModekweUgochukwu Uzodimma NnadozieRadiation wounds are very difficult to manage due to poor vascular status, excessive matrix metalloproteinases, and abnormal myofibroblast function. Such wound beds do not adequately support conventional resurfacing as do nonradiate beds. We present a 46-year-old female with a sacral radiation ulcer, which had earlier failed to support flap cover on two instances after bed preparation with conventional honey dressing and negative pressure dressing, but was subsequently successfully managed with unripe pawpaw wound bed preparation. A re-elevation of the right gluteal myocutaneous flap proved successful and satisfactory. The finding may have resulted from both enzymatic properties of unripe pawpaw and its ability to break the biofilms and to locally supply the ascorbic acid necessary for collagen synthesis and granulation tissue formation.http://www.njmonline.org/article.asp?issn=1115-2613;year=2021;volume=30;issue=3;spage=339;epage=341;aulast=Nwankwocase reportradiation woundsunripe pawpawwound bed preparation |
| spellingShingle | Ezekiel Uchechukwu Nwankwo Charles Chidiebele Maduba Victor Ifeanyichukwu Modekwe Ugochukwu Uzodimma Nnadozie The use of unripe pawpaw for wound bed preparation following radiation-induced sacral ulcer: A case report and review of literature Nigerian Journal of Medicine case report radiation wounds unripe pawpaw wound bed preparation |
| title | The use of unripe pawpaw for wound bed preparation following radiation-induced sacral ulcer: A case report and review of literature |
| title_full | The use of unripe pawpaw for wound bed preparation following radiation-induced sacral ulcer: A case report and review of literature |
| title_fullStr | The use of unripe pawpaw for wound bed preparation following radiation-induced sacral ulcer: A case report and review of literature |
| title_full_unstemmed | The use of unripe pawpaw for wound bed preparation following radiation-induced sacral ulcer: A case report and review of literature |
| title_short | The use of unripe pawpaw for wound bed preparation following radiation-induced sacral ulcer: A case report and review of literature |
| title_sort | use of unripe pawpaw for wound bed preparation following radiation induced sacral ulcer a case report and review of literature |
| topic | case report radiation wounds unripe pawpaw wound bed preparation |
| url | http://www.njmonline.org/article.asp?issn=1115-2613;year=2021;volume=30;issue=3;spage=339;epage=341;aulast=Nwankwo |
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