Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7 Breast Cancer Cells
A series of chalcones was synthesized to be (E)-1-(4-chlorophenyl)-3-p-tolyprop-2-en-1-on (1), (E)-1-(4-chlorophenyl)-3-(4-tolyprophenyl) prop-2-en-1-on (2), (E)-1-(3-bromophenyl)-3-p-tolylprop-2-en-1-on (3), and (E)-1-(3-bromophenyl)-3-(4-isopropyl phenyl) prop-2-en-1-on (4) using irradiate microwa...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2022-05-01
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| Series: | Indonesian Journal of Chemistry |
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| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/69991 |
| _version_ | 1818253423404908544 |
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| author | Eti Meirina Brahmana Jamaran Kaban Ginda Haro Mimpin Ginting |
| author_facet | Eti Meirina Brahmana Jamaran Kaban Ginda Haro Mimpin Ginting |
| author_sort | Eti Meirina Brahmana |
| collection | DOAJ |
| description | A series of chalcones was synthesized to be (E)-1-(4-chlorophenyl)-3-p-tolyprop-2-en-1-on (1), (E)-1-(4-chlorophenyl)-3-(4-tolyprophenyl) prop-2-en-1-on (2), (E)-1-(3-bromophenyl)-3-p-tolylprop-2-en-1-on (3), and (E)-1-(3-bromophenyl)-3-(4-isopropyl phenyl) prop-2-en-1-on (4) using irradiate microwave method with reaction time from 3, 6, and 8 min at 800 °C and 700 W. The compounds were characterized using TLC, UV-Vis, FTIR, 1H-NMR, and evaluated MCF-7 cancer cell cytotoxic test with Presto BlueTM. All compounds produced were in the form of yellow crystals. The results showed that compounds 2, 3, and 4 were potentially a Como prevention agent and inhibit cell proliferation with IC50 values of 37.24, 422.22, and 22.41 ppm, respectively. While compound 1 had IC50 1,484.75 and no cytotoxic effect. Further tests should be carried out for compounds 2, 3, and 4 against normal cells to measure the compound's safety for normal cells. |
| first_indexed | 2024-12-12T16:39:50Z |
| format | Article |
| id | doaj.art-faf5a16a39e94826a7ae8cccb7a0f105 |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-12-12T16:39:50Z |
| publishDate | 2022-05-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-faf5a16a39e94826a7ae8cccb7a0f1052022-12-22T00:18:35ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782022-05-0122368369110.22146/ijc.6999131773Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7 Breast Cancer CellsEti Meirina Brahmana0Jamaran Kaban1Ginda Haro2Mimpin Ginting3Postgraduate School, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, Indonesia; Biology Study Program, Faculty of Teaching Training and Education, Universitas Pasir Pengaraian, Riau 28557, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, IndonesiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No. 5, Medan 20155, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, IndonesiaA series of chalcones was synthesized to be (E)-1-(4-chlorophenyl)-3-p-tolyprop-2-en-1-on (1), (E)-1-(4-chlorophenyl)-3-(4-tolyprophenyl) prop-2-en-1-on (2), (E)-1-(3-bromophenyl)-3-p-tolylprop-2-en-1-on (3), and (E)-1-(3-bromophenyl)-3-(4-isopropyl phenyl) prop-2-en-1-on (4) using irradiate microwave method with reaction time from 3, 6, and 8 min at 800 °C and 700 W. The compounds were characterized using TLC, UV-Vis, FTIR, 1H-NMR, and evaluated MCF-7 cancer cell cytotoxic test with Presto BlueTM. All compounds produced were in the form of yellow crystals. The results showed that compounds 2, 3, and 4 were potentially a Como prevention agent and inhibit cell proliferation with IC50 values of 37.24, 422.22, and 22.41 ppm, respectively. While compound 1 had IC50 1,484.75 and no cytotoxic effect. Further tests should be carried out for compounds 2, 3, and 4 against normal cells to measure the compound's safety for normal cells.https://jurnal.ugm.ac.id/ijc/article/view/69991breast cancerchalconesmcf-7 cancer cell |
| spellingShingle | Eti Meirina Brahmana Jamaran Kaban Ginda Haro Mimpin Ginting Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7 Breast Cancer Cells Indonesian Journal of Chemistry breast cancer chalcones mcf-7 cancer cell |
| title | Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7 Breast Cancer Cells |
| title_full | Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7 Breast Cancer Cells |
| title_fullStr | Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7 Breast Cancer Cells |
| title_full_unstemmed | Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7 Breast Cancer Cells |
| title_short | Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7 Breast Cancer Cells |
| title_sort | synthesis and cytotoxic test of halogen substituted chalcone against mcf 7 breast cancer cells |
| topic | breast cancer chalcones mcf-7 cancer cell |
| url | https://jurnal.ugm.ac.id/ijc/article/view/69991 |
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