Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea
IntroductionAlbuminuria is a well-known risk factor for end-stage kidney disease, all-cause mortality, and cardiovascular mortality, even when the albumin-to-creatinine ratio is <30 mg/g. However, the association between transiently observed trace albuminuria and these major adverse outcomes...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.882599/full |
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| author | Samel Park Jiyoung Woo Subeen Leem Nam Hun Heo Nam-Jun Cho Hyowook Gil Jae Heon Kim Eun Young Lee Eun Young Lee Eun Young Lee |
| author_facet | Samel Park Jiyoung Woo Subeen Leem Nam Hun Heo Nam-Jun Cho Hyowook Gil Jae Heon Kim Eun Young Lee Eun Young Lee Eun Young Lee |
| author_sort | Samel Park |
| collection | DOAJ |
| description | IntroductionAlbuminuria is a well-known risk factor for end-stage kidney disease, all-cause mortality, and cardiovascular mortality, even when the albumin-to-creatinine ratio is <30 mg/g. However, the association between transiently observed trace albuminuria and these major adverse outcomes has not yet been reported. This study aimed to examine the effect of transient albuminuria on these major adverse outcomes using the National Health Insurance Service data in Korea.Methods and ResultsThe National Health Insurance Service-National Sample Cohort from Korea, followed from 2002 to 2015, consisted of 1,025,340 individuals, accounting for 2.2% of the total Korean population. We analyzed the effect of transient albuminuria on all-cause death, cardiovascular death, and incident chronic kidney disease (CKD) and compared it with the group without albuminuria. Among 1,025,340 individuals, 121,876 and 2,815 had transient albuminuria and no albuminuria, respectively. Adjusted hazard ratios of the transient albuminuria group for cardiovascular death and incident CKD were 1.76 (1.01–3.08) and 1.28 (1.15–1.43), respectively. There were significant differences in all-cause death, cardiovascular death, and incident CKD between the two groups after propensity score matching (p = 0.0037, p = 0.015, and p < 0.0001, respectively). Propensity score matching with bootstrapping showed that the hazard ratios of the transient albuminuria group for all-cause death and cardiovascular death were 1.39 (1.01–1.92) and 2.18 (1.08–5.98), respectively.ConclusionsIn this nationwide, large-scale, retrospective cohort study, transient albuminuria was associated with all-cause death, cardiovascular death, and incident CKD, suggesting that transient albuminuria could be a risk marker for adverse outcomes in the future, and that its own subclinical phenotype could play an important role during the course of CKD. |
| first_indexed | 2024-04-14T05:04:10Z |
| format | Article |
| id | doaj.art-faf61465eb404838b95f29c3270d6e93 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-14T05:04:10Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-faf61465eb404838b95f29c3270d6e932022-12-22T02:10:49ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-05-01910.3389/fcvm.2022.882599882599Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in KoreaSamel Park0Jiyoung Woo1Subeen Leem2Nam Hun Heo3Nam-Jun Cho4Hyowook Gil5Jae Heon Kim6Eun Young Lee7Eun Young Lee8Eun Young Lee9Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, South KoreaDepartment of Bigdata Engineering, Soonchunhyang University, Asan, South KoreaDepartment of Bigdata Engineering, Soonchunhyang University, Asan, South KoreaDepartment of Biostatistics, Soonchunhyang University Cheonan Hospital, Cheonan, South KoreaDepartment of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, South KoreaDepartment of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, South KoreaDepartment of Urology, Soonchunhyang University Seoul Hospital, Seoul, South KoreaDepartment of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, South KoreaInstitute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan, South KoreaBK21 Four Project, College of Medicine, Soonchunhyang University, Cheonan, South KoreaIntroductionAlbuminuria is a well-known risk factor for end-stage kidney disease, all-cause mortality, and cardiovascular mortality, even when the albumin-to-creatinine ratio is <30 mg/g. However, the association between transiently observed trace albuminuria and these major adverse outcomes has not yet been reported. This study aimed to examine the effect of transient albuminuria on these major adverse outcomes using the National Health Insurance Service data in Korea.Methods and ResultsThe National Health Insurance Service-National Sample Cohort from Korea, followed from 2002 to 2015, consisted of 1,025,340 individuals, accounting for 2.2% of the total Korean population. We analyzed the effect of transient albuminuria on all-cause death, cardiovascular death, and incident chronic kidney disease (CKD) and compared it with the group without albuminuria. Among 1,025,340 individuals, 121,876 and 2,815 had transient albuminuria and no albuminuria, respectively. Adjusted hazard ratios of the transient albuminuria group for cardiovascular death and incident CKD were 1.76 (1.01–3.08) and 1.28 (1.15–1.43), respectively. There were significant differences in all-cause death, cardiovascular death, and incident CKD between the two groups after propensity score matching (p = 0.0037, p = 0.015, and p < 0.0001, respectively). Propensity score matching with bootstrapping showed that the hazard ratios of the transient albuminuria group for all-cause death and cardiovascular death were 1.39 (1.01–1.92) and 2.18 (1.08–5.98), respectively.ConclusionsIn this nationwide, large-scale, retrospective cohort study, transient albuminuria was associated with all-cause death, cardiovascular death, and incident CKD, suggesting that transient albuminuria could be a risk marker for adverse outcomes in the future, and that its own subclinical phenotype could play an important role during the course of CKD.https://www.frontiersin.org/articles/10.3389/fcvm.2022.882599/fullalbuminurialow-grade albuminuriacardiovascular mortalityall-cause mortalitychronic kidney disease |
| spellingShingle | Samel Park Jiyoung Woo Subeen Leem Nam Hun Heo Nam-Jun Cho Hyowook Gil Jae Heon Kim Eun Young Lee Eun Young Lee Eun Young Lee Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea Frontiers in Cardiovascular Medicine albuminuria low-grade albuminuria cardiovascular mortality all-cause mortality chronic kidney disease |
| title | Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea |
| title_full | Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea |
| title_fullStr | Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea |
| title_full_unstemmed | Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea |
| title_short | Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea |
| title_sort | transiently observed trace albuminuria on urine dipstick test is associated with all cause death cardiovascular death and incident chronic kidney disease a national health insurance service national sample cohort in korea |
| topic | albuminuria low-grade albuminuria cardiovascular mortality all-cause mortality chronic kidney disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.882599/full |
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