Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia

Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia

Mechanisms underlying delayed selective neuronal death after global cerebral ischemia remain to be clarified. Here, we report a critical role for tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) in the pathogenesis of cerebral ischemia. C57BL/6j mice were subjected to transient...

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Bibliographic Details
Main Authors: Min Cui, Limei Wang, Xiaohong Liang, Xuelian Ma, Yugang Liu, Mingfeng Yang, Kejing Liu, Xinbing Wei, Zhiqiang Zhou, Youhai H. Chen, Wensheng Sun
Format: Article
Language:English
Published: Elsevier 2010-08-01
Series:Neurobiology of Disease
Subjects:
TRAIL
DR5
Apoptosis
Brain ischemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000902

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