Anti-asthmatic miR-224-5p inhibits the FHL1/MAPK pathway to repress airway smooth muscle cell proliferation in a murine model of asthma-like airway inflammation

Anti-asthmatic miR-224-5p inhibits the FHL1/MAPK pathway to repress airway smooth muscle cell proliferation in a murine model of asthma-like airway inflammation

Abstract Background The proliferation of airway smooth muscle cells (ASMCs) contributes to the contractility and inflammation in the pathophysiology of asthma. This intrigued us to clarify the effect of microRNA (miR)-224-5p on biological characteristics of ASMCs in mice with asthma-like airway infl...

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Bibliographic Details
Main Authors: Zhifang Zhuang, Yanjuan Zhou, Jiao Xu, Leying Pan
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Allergy, Asthma & Clinical Immunology
Subjects:
MicroRNA-224-5p
Four-and-a-half LIM protein 1
MAPK pathway
Airway inflammation
Asthma
Airway smooth muscle cells
Online Access:https://doi.org/10.1186/s13223-022-00724-9

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