Function and Therapeutic Implications of tRNA Derived Small RNAs
tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from nascent RNA silencing, to post-transcriptional gen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.888424/full |
| _version_ | 1818024060827729920 |
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| author | Briana Wilson Anindya Dutta |
| author_facet | Briana Wilson Anindya Dutta |
| author_sort | Briana Wilson |
| collection | DOAJ |
| description | tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from nascent RNA silencing, to post-transcriptional gene silencing, and finally, to translational regulation. The length distribution, sequence diversity, and multifaceted functions of tRFs and tiRs positions them as attractive new models for small RNA therapeutics. In this review, we will discuss the principles of tRF biogenesis and function in order to highlight their therapeutic potential. |
| first_indexed | 2024-12-10T03:54:13Z |
| format | Article |
| id | doaj.art-faf8a845f2f747fbac307f98c233de6e |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-10T03:54:13Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-faf8a845f2f747fbac307f98c233de6e2022-12-22T02:03:10ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-04-01910.3389/fmolb.2022.888424888424Function and Therapeutic Implications of tRNA Derived Small RNAsBriana Wilson0Anindya Dutta1Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, United StatesDepartment of Genetics, University of Alabama, Birmingham, AL, United StatestRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from nascent RNA silencing, to post-transcriptional gene silencing, and finally, to translational regulation. The length distribution, sequence diversity, and multifaceted functions of tRFs and tiRs positions them as attractive new models for small RNA therapeutics. In this review, we will discuss the principles of tRF biogenesis and function in order to highlight their therapeutic potential.https://www.frontiersin.org/articles/10.3389/fmolb.2022.888424/fulltRNA fragmentsRNA therapeuticstranslation inhibitionpost-transcriptional regulation of gene expressionRNA silencing |
| spellingShingle | Briana Wilson Anindya Dutta Function and Therapeutic Implications of tRNA Derived Small RNAs Frontiers in Molecular Biosciences tRNA fragments RNA therapeutics translation inhibition post-transcriptional regulation of gene expression RNA silencing |
| title | Function and Therapeutic Implications of tRNA Derived Small RNAs |
| title_full | Function and Therapeutic Implications of tRNA Derived Small RNAs |
| title_fullStr | Function and Therapeutic Implications of tRNA Derived Small RNAs |
| title_full_unstemmed | Function and Therapeutic Implications of tRNA Derived Small RNAs |
| title_short | Function and Therapeutic Implications of tRNA Derived Small RNAs |
| title_sort | function and therapeutic implications of trna derived small rnas |
| topic | tRNA fragments RNA therapeutics translation inhibition post-transcriptional regulation of gene expression RNA silencing |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.888424/full |
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