Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020–2021: a prospective multicenter study
Abstract This prospective, 12-center study investigated the etiology and clinical characteristics of acute viral hepatitis (AVH) during 2020–2021 in South Korea, and the performance of different diagnostic methods for hepatitis E virus (HEV). We enrolled 428 patients with acute hepatitis, of whom 16...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40775-5 |
| _version_ | 1797576873640722432 |
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| author | Chan Young Jeong Gwang Hyeon Choi Eun Sun Jang Young Seok Kim Youn-Jae Lee In Hee Kim Sung Bum Cho Jae Hyun Yoon Kyung-Ah Kim Dae Hee Choi Woo Jin Chung Hyun-Jin Cho Seong Kyun Na Yun-Tae Kim Byung Seok Lee Sook-Hyang Jeong |
| author_facet | Chan Young Jeong Gwang Hyeon Choi Eun Sun Jang Young Seok Kim Youn-Jae Lee In Hee Kim Sung Bum Cho Jae Hyun Yoon Kyung-Ah Kim Dae Hee Choi Woo Jin Chung Hyun-Jin Cho Seong Kyun Na Yun-Tae Kim Byung Seok Lee Sook-Hyang Jeong |
| author_sort | Chan Young Jeong |
| collection | DOAJ |
| description | Abstract This prospective, 12-center study investigated the etiology and clinical characteristics of acute viral hepatitis (AVH) during 2020–2021 in South Korea, and the performance of different diagnostic methods for hepatitis E virus (HEV). We enrolled 428 patients with acute hepatitis, of whom 160 (37.4%) were diagnosed with AVH according to predefined serologic criteria. The clinical data and risk factors for AVH were analyzed. For hepatitis E patients, anti-HEV IgM and IgG were tested with two commercial ELISA kits (Abia and Wantai) with HEV-RNA real-time RT-PCR. HAV, HEV, HBV, HCV, Epstein-Barr virus (EBV), cytomegalovirus, and herpes simplex virus accounted for AVH in 78.8% (n = 126), 7.5% (n = 12), 3.1% (n = 5), 1.9% (n = 3), 6.9% (n = 11), 1.2% (n = 2), and 0.6% (n = 1) of 160 patients (median age, 43 years; men, 52.5%; median ALT, 2144 IU/L), respectively. Hospitalization, hemodialysis, and intensive care unit admission were required in 137 (86.7%), 5 (3.2%), and 1 (0.6%) patient, respectively. Two patients developed acute liver failure (1.3%), albeit without mortality or liver transplantation. Ingestion of uncooked clams/oysters and wild boars’ blood/bile was reported in 40.5% and 16.7% of patients with HAV and HEV, respectively. The concordance rate between the anti-HEV-IgM results of both ELISA kits was 50%. HEV RNA was detected in only 17% of patients with HEV. The diagnosis of HEV needs clinical consideration due to incomplete HEV diagnostics. |
| first_indexed | 2024-03-10T21:59:56Z |
| format | Article |
| id | doaj.art-fafa880fc5b24078b6f1ef3ae7d720e0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T21:59:56Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fafa880fc5b24078b6f1ef3ae7d720e02023-11-19T12:59:46ZengNature PortfolioScientific Reports2045-23222023-08-0113111010.1038/s41598-023-40775-5Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020–2021: a prospective multicenter studyChan Young Jeong0Gwang Hyeon Choi1Eun Sun Jang2Young Seok Kim3Youn-Jae Lee4In Hee Kim5Sung Bum Cho6Jae Hyun Yoon7Kyung-Ah Kim8Dae Hee Choi9Woo Jin Chung10Hyun-Jin Cho11Seong Kyun Na12Yun-Tae Kim13Byung Seok Lee14Sook-Hyang Jeong15Departments of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of MedicineDepartments of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of MedicineDepartments of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of MedicineDepartment of Internal Medicine, Soonchunhyang University Bucheon HospitalDepartment of Internal Medicine, Inje University Busan Paik HospitalDepartment of Internal Medicine, Jeonbuk National University HospitalDepartment of Internal Medicine, Chonnam National University Hwasun HospitalDepartment of Internal Medicine, Chonnam National University HospitalDepartments of Internal Medicine, Inje University Ilsan Paik HospitalDepartments of Internal Medicine, Kangwon National University HospitalDepartments of Internal Medicine, Keimyung University Dongsan HospitalDepartments of Internal Medicine, Gyeongsang National University HospitalDepartments of Internal Medicine, Jeju National University HospitalSeoul Clinical LaboratoriesDepartments of Internal Medicine, Chungnam National University HospitalDepartments of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of MedicineAbstract This prospective, 12-center study investigated the etiology and clinical characteristics of acute viral hepatitis (AVH) during 2020–2021 in South Korea, and the performance of different diagnostic methods for hepatitis E virus (HEV). We enrolled 428 patients with acute hepatitis, of whom 160 (37.4%) were diagnosed with AVH according to predefined serologic criteria. The clinical data and risk factors for AVH were analyzed. For hepatitis E patients, anti-HEV IgM and IgG were tested with two commercial ELISA kits (Abia and Wantai) with HEV-RNA real-time RT-PCR. HAV, HEV, HBV, HCV, Epstein-Barr virus (EBV), cytomegalovirus, and herpes simplex virus accounted for AVH in 78.8% (n = 126), 7.5% (n = 12), 3.1% (n = 5), 1.9% (n = 3), 6.9% (n = 11), 1.2% (n = 2), and 0.6% (n = 1) of 160 patients (median age, 43 years; men, 52.5%; median ALT, 2144 IU/L), respectively. Hospitalization, hemodialysis, and intensive care unit admission were required in 137 (86.7%), 5 (3.2%), and 1 (0.6%) patient, respectively. Two patients developed acute liver failure (1.3%), albeit without mortality or liver transplantation. Ingestion of uncooked clams/oysters and wild boars’ blood/bile was reported in 40.5% and 16.7% of patients with HAV and HEV, respectively. The concordance rate between the anti-HEV-IgM results of both ELISA kits was 50%. HEV RNA was detected in only 17% of patients with HEV. The diagnosis of HEV needs clinical consideration due to incomplete HEV diagnostics.https://doi.org/10.1038/s41598-023-40775-5 |
| spellingShingle | Chan Young Jeong Gwang Hyeon Choi Eun Sun Jang Young Seok Kim Youn-Jae Lee In Hee Kim Sung Bum Cho Jae Hyun Yoon Kyung-Ah Kim Dae Hee Choi Woo Jin Chung Hyun-Jin Cho Seong Kyun Na Yun-Tae Kim Byung Seok Lee Sook-Hyang Jeong Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020–2021: a prospective multicenter study Scientific Reports |
| title | Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020–2021: a prospective multicenter study |
| title_full | Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020–2021: a prospective multicenter study |
| title_fullStr | Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020–2021: a prospective multicenter study |
| title_full_unstemmed | Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020–2021: a prospective multicenter study |
| title_short | Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020–2021: a prospective multicenter study |
| title_sort | etiology and clinical characteristics of acute viral hepatitis in south korea during 2020 2021 a prospective multicenter study |
| url | https://doi.org/10.1038/s41598-023-40775-5 |
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