Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor

Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor

Motor dysfunction in Parkinson’s disease (PD) is closely linked to the dopaminergic depletion of striatal neurons and altered synaptic plasticity at corticostriatal synapses. Dopamine receptor D1 (DRD1) stimulation is a crucial step in the formation of long-term potentiation (LTP), whereas dopamine...

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Bibliographic Details
Main Authors: Maurilyn Ayon-Olivas, Daniel Wolf, Thomas Andreska, Noelia Granado, Patrick Lüningschrör, Chi Wang Ip, Rosario Moratalla, Michael Sendtner
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biology
Subjects:
BDNF
TrkB
cortico-striatal synapse
basal ganglia
indirect pathway
DRD2
Online Access:https://www.mdpi.com/2079-7737/12/10/1360

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