Effects of actuation of nanoporous gold on cell orientation in a fibroblast sheet
Abstract Mechanical stimulation such as flood flow often plays a vital role in the growth and maintenance of a living body, and it is important to investigate cell responses to mechanical stimulation. To date, cell responses to mechanical stimulation have been investigated in detail. However, the ce...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2021-08-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Online Access: | https://doi.org/10.1007/s10856-021-06584-w |
| _version_ | 1818611646521671680 |
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| author | Peizheng Wu Shogo Sawaki Masataka Hakamada Mamoru Mabuchi |
| author_facet | Peizheng Wu Shogo Sawaki Masataka Hakamada Mamoru Mabuchi |
| author_sort | Peizheng Wu |
| collection | DOAJ |
| description | Abstract Mechanical stimulation such as flood flow often plays a vital role in the growth and maintenance of a living body, and it is important to investigate cell responses to mechanical stimulation. To date, cell responses to mechanical stimulation have been investigated in detail. However, the cell responses have been little known in a cell sheet. In the present study, a small cyclic strain (CS) of ~0.5% generated by a nanoporous gold actuator was loaded on a cell sheet of fibroblasts, and the effects of the CS on cell orientation were investigated. Individual cells were randomly distributed after the CS application, whereas cells were oriented in a specific direction after the CS application for the cell sheet. Thus, the CS had a different effect on the cell sheet from that on the individual cells. It is suggested that the cadherin/p-120 catenin complex played an important role in the cell response to mechanical stimulation in a cell sheet. |
| first_indexed | 2024-12-16T15:33:38Z |
| format | Article |
| id | doaj.art-fafb288054a246e78dad57842c064b21 |
| institution | Directory Open Access Journal |
| issn | 0957-4530 1573-4838 |
| language | English |
| last_indexed | 2024-12-16T15:33:38Z |
| publishDate | 2021-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj.art-fafb288054a246e78dad57842c064b212022-12-21T22:26:17ZengSpringerJournal of Materials Science: Materials in Medicine0957-45301573-48382021-08-013291510.1007/s10856-021-06584-wEffects of actuation of nanoporous gold on cell orientation in a fibroblast sheetPeizheng Wu0Shogo Sawaki1Masataka Hakamada2Mamoru Mabuchi3Graduate School of Energy Science, Kyoto UniversityGraduate School of Energy Science, Kyoto UniversityGraduate School of Energy Science, Kyoto UniversityGraduate School of Energy Science, Kyoto UniversityAbstract Mechanical stimulation such as flood flow often plays a vital role in the growth and maintenance of a living body, and it is important to investigate cell responses to mechanical stimulation. To date, cell responses to mechanical stimulation have been investigated in detail. However, the cell responses have been little known in a cell sheet. In the present study, a small cyclic strain (CS) of ~0.5% generated by a nanoporous gold actuator was loaded on a cell sheet of fibroblasts, and the effects of the CS on cell orientation were investigated. Individual cells were randomly distributed after the CS application, whereas cells were oriented in a specific direction after the CS application for the cell sheet. Thus, the CS had a different effect on the cell sheet from that on the individual cells. It is suggested that the cadherin/p-120 catenin complex played an important role in the cell response to mechanical stimulation in a cell sheet.https://doi.org/10.1007/s10856-021-06584-w |
| spellingShingle | Peizheng Wu Shogo Sawaki Masataka Hakamada Mamoru Mabuchi Effects of actuation of nanoporous gold on cell orientation in a fibroblast sheet Journal of Materials Science: Materials in Medicine |
| title | Effects of actuation of nanoporous gold on cell orientation in a fibroblast sheet |
| title_full | Effects of actuation of nanoporous gold on cell orientation in a fibroblast sheet |
| title_fullStr | Effects of actuation of nanoporous gold on cell orientation in a fibroblast sheet |
| title_full_unstemmed | Effects of actuation of nanoporous gold on cell orientation in a fibroblast sheet |
| title_short | Effects of actuation of nanoporous gold on cell orientation in a fibroblast sheet |
| title_sort | effects of actuation of nanoporous gold on cell orientation in a fibroblast sheet |
| url | https://doi.org/10.1007/s10856-021-06584-w |
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