The Most Common Cow's Milk Allergenic Proteins with Respect to Allergic Symptoms in Iranian Patients
Cow's milk allergy (CMA) is an immunological response to cow's milk proteins such as casein, α-lactalbumin and β lactoglobulin. The aim of this study was to determine the most common cow's milk allergenic proteins in patients with CMA and identify the most effective proteins in differ...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-04-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/686 |
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| author | Raheleh Shokouhi Shoormasti Mohammad Reza Fazlollahi Saeedeh Barzegar Pegah Teymourpour Zahra Yazdanyar Zahra Lebaschi Maryam Nourizadeh Behnaz Tazesh Masoud Movahedi Homa Kashani Zahra Pourpak Mostafa Moin |
| author_facet | Raheleh Shokouhi Shoormasti Mohammad Reza Fazlollahi Saeedeh Barzegar Pegah Teymourpour Zahra Yazdanyar Zahra Lebaschi Maryam Nourizadeh Behnaz Tazesh Masoud Movahedi Homa Kashani Zahra Pourpak Mostafa Moin |
| author_sort | Raheleh Shokouhi Shoormasti |
| collection | DOAJ |
| description | Cow's milk allergy (CMA) is an immunological response to cow's milk proteins such as casein, α-lactalbumin and β lactoglobulin. The aim of this study was to determine the most common cow's milk allergenic proteins in patients with CMA and identify the most effective proteins in different allergic symptoms. Eighty seven patients (≤18 years) with allergy to cow’s milk from 2006 to 2013 entered this study. They had a positive history of allergic reactions to cow’s milk and a positive specific IgE test to whole cow's milk. The patients’ symptoms were divided into four groups. Serum specific IgEs against four different main proteins of cow's milk were measured using RIDA Allergy Screen. Among 87 patients, 53 (60.5%) were male and the median age was 2.5 years. The frequency of respiratory, skin, gastrointestinal symptoms, and anaphylaxis were 63.3%, 55.7%, 20.3%, and 13.4%, respectively. Specific IgEs to total cow's milk protein (n=75, 89.3%), and the main Cow’s Milk Proteins including α-lactalbumin (n=65, 77.4%), casein (n=64, 75.3%), β-lactoglobulin (n=52, 62.7%), and bovine serum albumin (n=35, 44.9%) were detected. Specific IgE tests to β-lactoglobulin were positive in 90% of the patients with anaphylaxis. Moreover, significant relationship was found between specific IgE to β-lactoglobulin and anaphylaxis (p=0.04). Although it is presumed that α-lactalbumin and casein are the most common allergenic proteins of cow's milk, in this study there is a significant relationship between the anaphylaxis and the presence of β-lactoglobulin-specific IgE. Therefore, more precautions are recommended due to possible anaphylactic reactions in patients with a positive test history for β-lactoglobulin specific IgE. |
| first_indexed | 2024-12-14T02:40:05Z |
| format | Article |
| id | doaj.art-fafca877fd0243ce826e82c23acffa39 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-14T02:40:05Z |
| publishDate | 2016-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-fafca877fd0243ce826e82c23acffa392022-12-21T23:20:02ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492016-04-01152595The Most Common Cow's Milk Allergenic Proteins with Respect to Allergic Symptoms in Iranian PatientsRaheleh Shokouhi Shoormasti0Mohammad Reza Fazlollahi1Saeedeh Barzegar2Pegah Teymourpour3Zahra Yazdanyar4Zahra Lebaschi5Maryam Nourizadeh6Behnaz Tazesh7Masoud Movahedi8Homa Kashani9Zahra Pourpak10Mostafa Moin11Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IranImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IranImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IranImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IranImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IranImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IranImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IranImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Immunology and Allergy, Children Medical Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IranImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran AND Department of Immunology and Allergy, Children Medical Center, Tehran University of Medical Sciences, Tehran, IranCow's milk allergy (CMA) is an immunological response to cow's milk proteins such as casein, α-lactalbumin and β lactoglobulin. The aim of this study was to determine the most common cow's milk allergenic proteins in patients with CMA and identify the most effective proteins in different allergic symptoms. Eighty seven patients (≤18 years) with allergy to cow’s milk from 2006 to 2013 entered this study. They had a positive history of allergic reactions to cow’s milk and a positive specific IgE test to whole cow's milk. The patients’ symptoms were divided into four groups. Serum specific IgEs against four different main proteins of cow's milk were measured using RIDA Allergy Screen. Among 87 patients, 53 (60.5%) were male and the median age was 2.5 years. The frequency of respiratory, skin, gastrointestinal symptoms, and anaphylaxis were 63.3%, 55.7%, 20.3%, and 13.4%, respectively. Specific IgEs to total cow's milk protein (n=75, 89.3%), and the main Cow’s Milk Proteins including α-lactalbumin (n=65, 77.4%), casein (n=64, 75.3%), β-lactoglobulin (n=52, 62.7%), and bovine serum albumin (n=35, 44.9%) were detected. Specific IgE tests to β-lactoglobulin were positive in 90% of the patients with anaphylaxis. Moreover, significant relationship was found between specific IgE to β-lactoglobulin and anaphylaxis (p=0.04). Although it is presumed that α-lactalbumin and casein are the most common allergenic proteins of cow's milk, in this study there is a significant relationship between the anaphylaxis and the presence of β-lactoglobulin-specific IgE. Therefore, more precautions are recommended due to possible anaphylactic reactions in patients with a positive test history for β-lactoglobulin specific IgE.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/686α-lactalbuminβ-lactoglobulinBovine serum albuminCaseinCow's milk allergyCow's milk proteins |
| spellingShingle | Raheleh Shokouhi Shoormasti Mohammad Reza Fazlollahi Saeedeh Barzegar Pegah Teymourpour Zahra Yazdanyar Zahra Lebaschi Maryam Nourizadeh Behnaz Tazesh Masoud Movahedi Homa Kashani Zahra Pourpak Mostafa Moin The Most Common Cow's Milk Allergenic Proteins with Respect to Allergic Symptoms in Iranian Patients Iranian Journal of Allergy, Asthma and Immunology α-lactalbumin β-lactoglobulin Bovine serum albumin Casein Cow's milk allergy Cow's milk proteins |
| title | The Most Common Cow's Milk Allergenic Proteins with Respect to Allergic Symptoms in Iranian Patients |
| title_full | The Most Common Cow's Milk Allergenic Proteins with Respect to Allergic Symptoms in Iranian Patients |
| title_fullStr | The Most Common Cow's Milk Allergenic Proteins with Respect to Allergic Symptoms in Iranian Patients |
| title_full_unstemmed | The Most Common Cow's Milk Allergenic Proteins with Respect to Allergic Symptoms in Iranian Patients |
| title_short | The Most Common Cow's Milk Allergenic Proteins with Respect to Allergic Symptoms in Iranian Patients |
| title_sort | most common cow s milk allergenic proteins with respect to allergic symptoms in iranian patients |
| topic | α-lactalbumin β-lactoglobulin Bovine serum albumin Casein Cow's milk allergy Cow's milk proteins |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/686 |
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