Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease
Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment. The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s dis...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=9;spage=1626;epage=1634;aulast=Reza-Zaldivar |
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| author | Edwin E Reza-Zaldivar Mercedes A Hernández-Sapiéns Yanet K Gutiérrez-Mercado Sergio Sandoval-Ávila Ulises Gomez-Pinedo Ana L Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A Canales-Aguirre |
| author_facet | Edwin E Reza-Zaldivar Mercedes A Hernández-Sapiéns Yanet K Gutiérrez-Mercado Sergio Sandoval-Ávila Ulises Gomez-Pinedo Ana L Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A Canales-Aguirre |
| author_sort | Edwin E Reza-Zaldivar |
| collection | DOAJ |
| description | Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment. The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease. Alzheimer’s disease mouse models were established by injection of beta amyloid 1−42 aggregates into dentate gyrus bilaterally. Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration. Afterwards, neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies. Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1−42-induced cognitive impairment, and these effects are similar to those shown in the mesenchymal stem cells. These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease. All procedures and experiments were approved by Institutional Animal Care and Use Committee (CICUAL) (approval No. CICUAL 2016-011) on April 25, 2016. |
| first_indexed | 2024-12-12T06:52:53Z |
| format | Article |
| id | doaj.art-fafd8c635c1a45e78c3d34670b3ee6a7 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-12T06:52:53Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-fafd8c635c1a45e78c3d34670b3ee6a72022-12-22T00:34:01ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742019-01-011491626163410.4103/1673-5374.255978Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s diseaseEdwin E Reza-ZaldivarMercedes A Hernández-SapiénsYanet K Gutiérrez-MercadoSergio Sandoval-ÁvilaUlises Gomez-PinedoAna L Márquez-AguirreEstefanía Vázquez-MéndezEduardo Padilla-CamberosAlejandro A Canales-AguirreStudies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment. The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease. Alzheimer’s disease mouse models were established by injection of beta amyloid 1−42 aggregates into dentate gyrus bilaterally. Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration. Afterwards, neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies. Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1−42-induced cognitive impairment, and these effects are similar to those shown in the mesenchymal stem cells. These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease. All procedures and experiments were approved by Institutional Animal Care and Use Committee (CICUAL) (approval No. CICUAL 2016-011) on April 25, 2016.http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=9;spage=1626;epage=1634;aulast=Reza-ZaldivarAlzheimer′s disease; neurodegenerative disease; cognitive impairment; memory; Alzheimer′s disease mouse model; mesenchymal stem cell; exosomes; neurogenesis; cognitive improvement; cell-free therapy; neural regeneration |
| spellingShingle | Edwin E Reza-Zaldivar Mercedes A Hernández-Sapiéns Yanet K Gutiérrez-Mercado Sergio Sandoval-Ávila Ulises Gomez-Pinedo Ana L Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A Canales-Aguirre Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease Neural Regeneration Research Alzheimer′s disease; neurodegenerative disease; cognitive impairment; memory; Alzheimer′s disease mouse model; mesenchymal stem cell; exosomes; neurogenesis; cognitive improvement; cell-free therapy; neural regeneration |
| title | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease |
| title_full | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease |
| title_fullStr | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease |
| title_full_unstemmed | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease |
| title_short | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease |
| title_sort | mesenchymal stem cell derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of alzheimer s disease |
| topic | Alzheimer′s disease; neurodegenerative disease; cognitive impairment; memory; Alzheimer′s disease mouse model; mesenchymal stem cell; exosomes; neurogenesis; cognitive improvement; cell-free therapy; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=9;spage=1626;epage=1634;aulast=Reza-Zaldivar |
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